d-KLA Peptide
Based on 1 Customer Validation
d-KLA Peptide (D-(KLAKLAK)2), KLA peptide (HY-P5345) isomer, is a pro-apoptosis peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide increases caspase 3/7 activity, exerts proapoptotic activity and enhances antitumor efficacy in mouse melanoma models.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.33%
- CAS 番号: 286380-05-0
- 分子式: C72H138N20O15
- 分子量:1523.99
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
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Caspase-3 |
Caspase-7 |
d-KLA Peptide (400 μM) kills 50% of eukaryotic cells in the monolayer[1].
d-KLA Peptide induces mitochondrial swelling in a cell-free system with an ED50 of 0.44 μM[1].
d-KLA Peptide induces mitochondrial membrane potential loss in a cell-free system with an ED50 of 0.4 μM[1].
d-KLA Peptide (1.5 μM in 1 μM ODN; 24 h) can form liposomes, which can reduce the viability of B16 (F10) mouse melanoma cells and enhance caspase 3/7 activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, initial weight 24.4 g, subcutaneous B16(F10) melanoma model)[1]
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Dosage:1.52 µg with G3139 (4 µg) in cationic liposome
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Administration:intratumoral; twice daily for 2 doses; intratumoral
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Result:Reduced tumor volume increase to 186% by day 4 post-treatment, compared to 470% for untreated controls.
Achieved a tumor growth inhibition (TGI) of 60%.
Induced significant apoptosis in tumor tissues as evidenced by bright green staining of apoptotic nuclei in TUNEL assays.
化学情報
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CAS 番号 286380-05-0
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性状 Solid
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分子量 1523.99
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分子式 C72H138N20O15
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Color White to off-white
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別名
D-(KLAKLAK)2
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配列
d-{Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys}
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シーケンスの短縮
d-{KLAKLAKKLAKLAK}
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
H2O : 25 mg/mL (16.40 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6562 mL | 3.2809 mL | 6.5617 mL | 16.4043 mL |
| 5 mM | 0.1312 mL | 0.6562 mL | 1.3123 mL | 3.2809 mL | |
| 10 mM | 0.0656 mL | 0.3281 mL | 0.6562 mL | 1.6404 mL | |
| 15 mM | 0.0437 mL | 0.2187 mL | 0.4374 mL | 1.0936 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
d-KLA Peptide 関連分類
HY-P10285 関連分類
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- d-KLA Peptide
- 286380-05-0
- D-(KLAKLAK)2
- Apoptosis
- Mitochondrial Metabolism
- Caspase
- cancer cells
- prokaryotic cytoplasmic membranes
- mouse melanoma models
- caspase 3/7
- mitochondrial membranes
- B16(F10) mouse melanoma cells
- mitochondrial-dependent apoptosis
- melanoma
- apoptosis
- eukaryotic plasma membranes
- Inhibitor
- inhibitor
- inhibit