Degalactotigonin
Degalactotigonin is a saponin-selective inhibitor targeting the EGFR, GSK3β and Hedgehog/Gli1 pathways and can be isolated from Solanum nigrum (Solanum nigrum). Degalactotigonin inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, and at the same time inhibits the Hedgehog/Gli1 pathway through GSK3β inactivation, thereby inducing cancer cell apoptosis, arresting the cell cycle, and inhibiting migration and invasion. Degalactotigonin can be used in targeted research on malignant tumors such as pancreatic cancer and osteosarcoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 39941-51-0
- 分子式: C50H82O22
- 分子量:1035.17
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
EGFR アイソフォーム固有の製品をすべて表示
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生物活性
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GSK-3β |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
15.44 μM
Compound: DGT
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Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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10.1039/C5MD00502G |
| HepG2 | IC50 |
0.25 μM
Compound: 1, degalactotigonin
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Cytotoxicity against human Hep G2 after 48 hrs by MTT assay
Cytotoxicity against human Hep G2 after 48 hrs by MTT assay
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[PMID: 16933867] |
| MCF7 | IC50 |
1.57 μM
Compound: 1, degalactotigonin
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Cytotoxicity against human MCF7 after 48 hrs by MTT assay
Cytotoxicity against human MCF7 after 48 hrs by MTT assay
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[PMID: 16933867] |
| MCF7 | IC50 |
8.27 μM
Compound: DGT
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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10.1039/C5MD00502G |
| MOLT-4 | IC50 |
11.72 μM
Compound: DGT
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Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MOLT4 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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10.1039/C5MD00502G |
| NCI-H460 | IC50 |
4.49 μM
Compound: 1, degalactotigonin
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Cytotoxicity against human NCI-H460 after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 after 48 hrs by MTT assay
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[PMID: 16933867] |
| SF-268 | IC50 |
3.19 μM
Compound: 1, degalactotigonin
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Cytotoxicity against human SF-268 after 48 hrs by MTT assay
Cytotoxicity against human SF-268 after 48 hrs by MTT assay
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[PMID: 16933867] |
| SK-BR-3 | IC50 |
9.33 μM
Compound: DGT
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Cytotoxicity against human SKBR3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human SKBR3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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10.1039/C5MD00502G |
化学情報
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CAS 番号 39941-51-0
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分子量 1035.17
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分子式 C50H82O22
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SMILES
C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](CO4)C)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6([C@@](C[C@H](CC6)O[C@]7([H])O[C@@H]([C@@H]([C@@H]([C@H]7O)O)O[C@@]8([H])[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O[C@@]9([H])[C@@H]([C@H]([C@@H](CO9)O)O)O)O[C@]%10([H])O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)CO)CO)([H])CC5)C)([H])CC2
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Tuan Anh HL, et al. Degalactotigonin, a Steroidal Glycoside from Solanum nigrum, Induces Apoptosis and Cell Cycle Arrest via Inhibiting the EGFR Signaling Pathways in Pancreatic Cancer Cells. Biomed Res Int. 2018 Dec 16;2018:3120972. [Content Brief]
[2]. Zhao Z, et al. Degalactotigonin, a Natural Compound from Solanum nigrum L., Inhibits Growth and Metastasis of Osteosarcoma through GSK3β Inactivation-Mediated Repression of the Hedgehog/Gli1 Pathway. Clin Cancer Res. 2018 Jan 1;24(1):130-144. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Degalactotigonin 関連分類
HY-N9684 関連分類
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