ESD - esterase D Gene

Also Known as FGH

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 2098

About ESD

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:46,771,256-46,797,700 (from NCBI)

This gene has 5 transcripts (splice variants) and 245 orthologues. Ubiquitous expression in thyroid (RPKM 31.6), ovary (RPKM 31.3) and 25 other tissues.

Summary

This gene encodes a serine hydrolase that belongs to the esterase D family. The encoded enzyme is active toward numerous substrates including O-acetylated sialic acids, and it may be involved in the recycling of sialic acids. This gene is used as a genetic marker for retinoblastoma and Wilson's disease. [provided by RefSeq, Feb 2009]

ESD Products (1)

mRNA	Protein	Name
NM_001984.2	NP_001975.1	S-formylglutathione hydrolase

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables hydrolase activity, acting on ester bonds	IDA IDA: Inferred from direct assay	19126594	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ESD Protein Structure

Esterase

0
100
200
282 a.a.

Protein Preferred Names	Protein Names
S-formylglutathione hydrolase	esterase 10

ESD Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ESD	P10768	FSD2	Homo sapiens	A1L4K1	Y2H Array	25416956
Intra	ESD	P10768	ESD	Homo sapiens	P10768	Y2H Prey Pooling	32296183
Intra	ESD	P10768	PLCG2	Homo sapiens	P16885	Y2H Array	25814554
Intra	ESD	P10768	FSD2	Homo sapiens	A1L4K1	Y2H Array	32296183
Intra	ESD	P10768	ESD	Homo sapiens	P10768	Y2H Array	31515488
Intra	ESD	P10768	FSD2	Homo sapiens	A1L4K1	Y2H Array	31515488
Intra	ESD	P10768	ESD	Homo sapiens	P10768	Validated Y2H	32296183
Intra	ESD	P10768	CRK	Homo sapiens	P46108	Y2H Array	25814554
Intra	ESD	P10768	FSD2	Homo sapiens	A1L4K1	Validated Y2H	25416956
Intra	ESD	P10768	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	32296183
Intra	ESD	P10768	ESD	Homo sapiens	P10768	Y2H Array	32296183
Intra	ESD	P10768	ESD	Homo sapiens	P10768	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ESD Proteins

製品番号	製品名	アクセッション番号	純度
HY-P70279	Esterase D/FGH Protein, Human (His)	AAH01169.1 (M1-A282)	≥ 95%, as determined by reducing SDS-PAGE.

ESD 抗体

製品番号	製品名	アプリケーション	反応性
HY-P811232	ESD Antibody	WB, IHC-P	Human, Mouse, Rat
HY-P86867	ESD Antibody (YA6560)	WB	Human, Mouse, Rat

関連疾患

Diseases	Alias
Wilson Disease	Hepatolenticular Degeneration WD Wilson'S Disease WND Westphal-Strumpell Syndrome Copper Storage Disease Cerebral Pseudosclerosis Westphal Pseudosclerosis Hepatolenticular Degeneration Syndrome Copper Retention Hepatocerebral Degeneration Kinnier-Wilson Disease Neurohepatic Degeneration Progressive Hepatolenticular Degeneration Lenticular Degenerative Disease Wilson'S Syndrome Lenticular Syndrome
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Cervical Non-Keratinizing Squamous Cell Carcinoma
Dermoid Cyst Of Ovary	Dermoid Cyst Ovarian Dermoid Cyst Teratoma, Ovarian
Bilateral Retinoblastoma
Familial Retinoblastoma	Hereditary Retinoblastoma Retinoblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS04524	ESD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19859	Esd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26359	Esd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	ESD	MGD	MGI:95421
Felis catus	ESD	VGNC	VGNC:102197
Bos taurus	ESD	VGNC	VGNC:28600
Rattus norvegicus	ESD	RGD	RGD:1592114
Canis familiaris	ESD	VGNC	VGNC:40472
Macaca mulatta	ESD	VGNC	VGNC:103814
Others	ESD	NCBI