FABP5 - fatty acid binding protein 5 Gene

Also Known as EFABP; KFABP; E-FABP; PAFABP; PA-FABP

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 2171

About FABP5

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:81,280,536-81,284,775 (from NCBI)

This gene has 4 transcripts (splice variants), 447 orthologues and 15 paralogues. Biased expression in esophagus (RPKM 725.7), fat (RPKM 171.7) and 11 other tissues.

Summary

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in Psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain Fatty Acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with Type 2 Diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]

FABP5 Products (1)

mRNA Protein Name
NM_001444.3 NP_001435.1 fatty acid-binding protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables fatty acid binding IDA
IDA: Inferred from direct assay
8092987 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
24531463 GOA
enables long-chain fatty acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
21395585 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12839573 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in lipid transport across blood-brain barrier IMP
IMP: Inferred from mutant phenotype
21395585 GOA
involved in long-chain fatty acid transport IMP
IMP: Inferred from mutant phenotype
21395585 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in cytoplasm IDA
IDA: Inferred from direct assay
8092987 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24692551 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FABP5 Protein Structure

Lipocalin

Lipocalin: Lipocalin / cytosolic fatty-acid binding protein family (9 - 133)

  • 0
  • 100
  • 135 a.a.
Protein Preferred Names Protein Names

fatty acid-binding protein 5

  • epidermal-type fatty acid-binding protein

Recombinant FABP5 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P72660 FABP5 Protein, Human (His) Q01469 (A2-E135) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75214 FABP5 Protein, Human Q01469 (M1-E135) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Psoriasis
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-101903 BMS-309403 Inhibitor 99.84% Unkown
HY-101903A BMS-309403 sodium Inhibitor 99.89% Unkown
HY-145990 FABPs ligand 6 Inhibitor 99.86% Unkown
HY-161702 RO6806051 Inhibitor 99.82% Unkown
HY-160457 FABP4/5-IN-5 Inhibitor 98.10% Unkown
HY-N8144 Niga-ichigoside F1 99.0% Unkown
HY-RS04661 FABP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-178471 FABP4/5-IN-6 Inhibitor / Unkown
HY-183836 FABP4/5-IN-7 Inhibitor / Unkown
HY-160456 FABP4/5-IN-4 Inhibitor / Unkown
HY-RS16605 Fabp5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23039 Fabp5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus FABP5 RGD RGD:70997
Felis catus FABP5 VGNC VGNC:81655
Mus musculus FABP5 MGD MGI:101790
Others FABP5 NCBI