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ORC4 - origin recognition complex subunit 4 Gene

Also Known as ORC4L; ORC4P

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 5000

About ORC4

Cytogenetic location: 2q23.1 Genomic coordinates (GRCh38): 2:147,930,396-148,021,551 (from NCBI)

This gene has 16 transcripts (splice variants), 211 orthologues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 7.5), skin (RPKM 6.5) and 25 other tissues.

Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]

ORC4 Products (8)

mRNA	Protein	Name
NM_001190879.3	NP_001177808.1	origin recognition complex subunit 4 isoform 1
NM_001190881.3	NP_001177810.1	origin recognition complex subunit 4 isoform 2
NM_001190882.3	NP_001177811.1	origin recognition complex subunit 4 isoform 3
NM_001374270.1	NP_001361199.1	origin recognition complex subunit 4 isoform 1
NM_001374272.1	NP_001361201.1	origin recognition complex subunit 4 isoform 2
NM_002552.5	NP_002543.2	origin recognition complex subunit 4 isoform 1
NM_181741.4	NP_859525.1	origin recognition complex subunit 4 isoform 1
NM_181742.4	NP_859526.1	origin recognition complex subunit 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables DNA replication origin binding	IMP IMP: Inferred from mutant phenotype	9353276	GOA
enables nucleotide binding	IDA IDA: Inferred from direct assay	9353276	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15232106	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in DNA replication initiation	IDA IDA: Inferred from direct assay	16549788	GOA
involved in DNA replication initiation	IMP IMP: Inferred from mutant phenotype	9353276	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
colocalizes with chromosome, telomeric region	IDA IDA: Inferred from direct assay	24270157	GOA
part of nuclear origin of replication recognition complex	IDA IDA: Inferred from direct assay	20932478	GOA
part of nuclear origin of replication recognition complex	IPI IPI: Inferred from physical interaction	16549788	GOA
located in nucleus	IDA IDA: Inferred from direct assay	9353276	GOA
part of origin recognition complex	IDA IDA: Inferred from direct assay	17716973	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORC4 Protein Structure

AAA_16

ORC4_C

0
100
200
300
400
436 a.a.

Protein Preferred Names	Protein Names
origin recognition complex subunit 4	origin recognition complex, subunit 4 homolog

ORC4 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	ORC4	O43929	LACC1	Homo sapiens	Q8IV20	Anti Tag CoIP	33961781
Intra	ORC4	O43929	LACC1	Homo sapiens	Q8IV20	Anti Tag CoIP	28514442
Intra	ORC4	O43929	ORC6	Homo sapiens	Q9Y5N6	BiFC	18234858
Intra	ORC4	O43929	ORC3	Homo sapiens	Q9UBD5	Anti Bait CoIP	17716973
Intra	ORC4	O43929	ORC3	Homo sapiens	Q9UBD5	Protein Array	15232106
Intra	ORC4	O43929	ORC2	Homo sapiens	Q13416	Anti Bait CoIP	17716973
Intra	ORC4	O43929	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	ORC4	O43929	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	ORC4	O43929	RRM2B	Homo sapiens	Q7LG56	Validated Y2H	25416956
Intra	ORC4	O43929	RRM2B	Homo sapiens	Q7LG56	Y2H Array	25416956
Intra	ORC4	O43929	RRM2B	Homo sapiens	Q7LG56	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Meier-Gorlin Syndrome 2	MGORS2 Meier-Gorlin Syndrome, Type 2
Mbd5 Haploinsufficiency	2q23.1 Microdeletion Syndrome 2q23.1 Microduplication Syndrome Del(2)(Q23.1) Monosomy 2q23.1 Pseudo-Angelman Syndrome Mbd5 Associated Neurodevelopmental Disorder Chromosome 2q23.1 Microdeletion Syndrome Mbd5-Associated Neurodevelopmental Disorder Mand Dup(2)(Q23.1) Trisomy 2q23.1
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Meier-Gorlin Syndrome 7	MGORS7 Meier-Gorlin Syndrome, Type 7
Meier-Gorlin Syndrome 5	MGORS5 Meier-Gorlin Syndrome, Type 5
Microtia	Congenital Small Ears Hypoplasia Of Ear
Genitourinary Tract Anomalies
Isolated Growth Hormone Deficiency	Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Pituitary Dwarfism Dwarfism, Pituitary Isolated Somatotropin Deficiency Isolated Congenital Growth Hormone Deficiency Familial Isolated Growth Hormone Deficiency Ighd Dwarfism, Growth Hormone Deficiency Growth Hormone Deficiency Dwarfism Isolated Gh Deficiency Isolated Hgh Deficiency Isolated Human Growth Hormone Deficiency Isolated Somatotropin Deficiency Disorder Dwarfism Pituitary
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Nemaline Myopathy 2	NEM2 Nemaline Myopathy 2, Autosomal Recessive Nemaline Myopathy, Type 2 Neb-Related Nemaline Myopathy Myopathy, Nemaline, Type 2
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-180157	CDK2-IN-51	Inhibitor	/	Unkown
HY-RS09828	ORC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	ORC4	VGNC	VGNC:44143
Macaca mulatta	ORC4	VGNC	VGNC:75716
Felis catus	ORC4	VGNC	VGNC:68651
Mus musculus	ORC4	MGD	MGI:1347043
Rattus norvegicus	ORC4	RGD	RGD:735212
Bos taurus	ORC4	VGNC	VGNC:32449
Others	ORC4	NCBI