HDAC3-IN-5
HDAC3-IN-5 (9c) is a HDAC3 selective inhibitor, with IC50 values of 4.2 nM, 1629 nM and 298.2 nM for HDAC3, HDAC2, HDAC1, respectively. HDAC3-IN-5 (9c) can effectively induce apoptosisin MV4-11 cells in vitro and reduce the expression of anti-apoptotic proteins, the development of HDAC3 selective inhibitors may serve as a potential lead compound to reverse Venetoclax resistance.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3095232-95-1
- 分子式: C28H38N4O
- 分子量:446.63
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
|
HDAC3 4.2 nM (IC50) |
HDAC1 298.2 nM (IC50) |
HDAC2 1629 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| JeKo-1 | IC50 |
484 nM
Compound: 9c
|
Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
|
[PMID: 39047608] |
| K562 | IC50 |
383 nM
Compound: 9c
|
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
|
[PMID: 39047608] |
| MV4-11 | IC50 |
315 nM
Compound: 9c
|
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
|
[PMID: 39047608] |
化学情報
-
CAS 番号 3095232-95-1
-
分子量 446.63
-
分子式 C28H38N4O
-
SMILES
O=C(NNCCC)/C=C/C1=CC=C(CN(CCCC)CCC2=C(C)NC3=C2C=CC=C3)C=C1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)