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製品番号: HY-121372

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Lactandrate

Lactandrate is a D-high nitrogen steroid alkylating agent. It can interact with the ligand-binding domain (LBD) of estrogen receptor-alpha (ERα). Lactandrate has a growth inhibitory effect on breast cancer cells, with a GI₅₀ value ranging from 5 to 65 μM. It shows anti-tumor activity in mouse breast tumors (MXT and CD8F1) as well as in human xenograft MX-1.

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CAS 番号: 43000-65-3
分子式: C₃₁H₄₄Cl₂N₂O₃
分子量:563.60

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Lactandrate 構造式

CAS 番号: 43000-65-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
Hs 766	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
Hs 766	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human Hs766T cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
MCF7	GI₅₀	5 μM Compound: 104	Growth inhibition of human MCF7 cells after 48 h by MTT assay Growth inhibition of human MCF7 cells after 48 h by MTT assay	[PMID: 29649739]
MCF7	GI₅₀	5 μM Compound: 104	Growth inhibition of human MCF7 cells after 48 by MTT assay Growth inhibition of human MCF7 cells after 48 by MTT assay	[PMID: 29649739]
MIA PaCa-2	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
MIA PaCa-2	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human MIAPaCa2 cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
PANC-1	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 h by MTT assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 h by MTT assay	[PMID: 29649739]
PANC-1	IC₅₀	>100 μM Compound: 104	Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay Cytotoxicity against human PANC1 cells assessed as reduction in cell viability after 48 by MTT assay	[PMID: 29649739]
T47D	GI₅₀	5 μM Compound: 104	Growth inhibition of human T47D cells after 48 h by MTT assay Growth inhibition of human T47D cells after 48 h by MTT assay	[PMID: 29649739]
T47D	GI₅₀	5 μM Compound: 104	Growth inhibition of human T47D cells after 48 by MTT assay Growth inhibition of human T47D cells after 48 by MTT assay	[PMID: 29649739]

化学情報

CAS 番号 43000-65-3
分子量 563.60
分子式 C₃₁H₄₄Cl₂N₂O₃
SMILES

C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@H](CC2)OC(CC4=CC=C(C=C4)N(CCCl)CCCl)=O)([H])[C@@]5([H])[C@](CC3)(NC(CC5)=O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (264 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Trafalis DT, et al. Lactandrate: a D-homo-aza-androsterone alkylator in the treatment of breast cancer. Breast Cancer Res Treat. 2006 May;97(1):17-31. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Lactandrate

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Lactandrate 関連分類

HY-121372 関連分類