Mecbotamab vedotin
Based on 1 Customer Validation
Mecbotamab vedotin (BA3011) is a pH dependent antibody drug conjugate (ADC) targeting AXL. Mecbotamab vedotin can significantly inhibit AXL in DU145 cells and LCLC-103H cells and kills cells. Mecbotamab vedotin can be used for research on cancer such as lung cancer, pancreatic cancer and prostate cancer. The antibody component is Mecbotamab (HY-P9988), and the ADC toxin molecule is Monomethyl auristatin E (MMAE) (HY-15162).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.21%
- CAS 番号: 2460400-64-8
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保管条件:
-80°C, protect from light
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
AXL; BA301 γ1[1]
体外実験
Mecbotamab vedotin (0.1-10000 ng/mL) efficiently binds to AXL at pH 6.0 in DU145 cells (EC50 = 16 ng/mL), LCLC-103H cells (EC50 = 37 ng/mL), 293-huAXL (EC50 = 56 ng/mL) and 293-cynoAXL (EC50 = 20 ng/mL)[1].
Mecbotamab vedotin (0.01-10000 ng/mL, 3 days) exhibits significant cytotoxicity at pH 6.0 in DU145 cells (IC50 = 1466 ng/mL) and LCLC-103H cells (IC50 = 474 ng/mL) but is non-toxic to 293-F cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:DU145 cells, LCLC-103H cells and 293-F cells
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Concentration:0.01-10000 ng/mL
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Incubation Time:3 days
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Result:Significantly killed the DU145 cells (IC50 = 1466 ng/mL) and LCLC-103H cells (IC50 = 474 ng/mL) at pH 6.0.
Effectively killed the DU145 cells (IC50 = 5069 ng/mL) and LCLC-103H cells (IC50 = 1095 ng/mL) at pH 7.4.
Had no significant toxicity to 293-F cells.
体内実験
Mecbotamab vedotin (1-10 mg/kg, i.v., once every 4 days, for 4 times) significantly inhibits tumor growth in female NOD/SCID mice bearing MIA PaCa-2 tumors[1].
Mecbotamab vedotin (6-15 mg/kg, i.v., once every 4 days, for 6 times) significantly delayed tumor growth in male BALB/c nude mice bearing DU145 tumors[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:1×106 LCLC-103H cells injected female NOD/SCID mice[1]
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Dosage:1, 3 and 6 mg/kg
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Administration:Intravenous injection (i.v.), once every 4 days, for 6 times
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Result:Significantly inhibited tumor growth (TGI range of 114-115%) and the efficacy of the 3 and 6 mg/kg groups persisted until 57 days.
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Animal Model:1×106 MIA PaCa-2 cells injected female NOD/SCID mice[1]
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Dosage:1, 3, 6 and 10 mg/kg
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Administration:Intravenous injection (i.v.), once every 4 days, for 4 times
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Result:Resulted in a TGI of 59% in the 6 mg/kg group and complete tumor regression in the 10 mg/kg group.
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Animal Model:5×106 DU145 cells injected female NOD/SCID mice[1]
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Dosage:6, 10 and 15 mg/kg
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Administration:Intravenous injection (i.v.), once every 4 days, for 6 times
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Result:Showed persistent anti-tumor activity in the 10 and 15 mg/kg groups.
臨床実験
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2460400-64-8
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性状 Liquid
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Color Colorless to light yellow
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SMILES
[Mecbotamab vedotin]
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別名
BA3011; CAB-Axl-ADC; CAB-anti-Axl-ADC
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輸送条件
Shipping with dry ice.
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保管条件
-80°C, protect from light
純度とドキュメンテーション
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データシート (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Mecbotamab vedotin 関連分類
HY-145622 関連分類
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