MN-05
MN-05 is a dual neuroprotective and vasodilatory NMDA receptor inhibitor.MN-05 blocks calcium influx, reduces free radical production, and maintains mitochondrial membrane potential in cortical neurons exposed to glutamate.MN-05 dilates aortic rings against phenylephrine-induced contraction.MN-05 protects neurons against glutamate-induced injury in vitro.MN-05 can be used for the research of neurodegenerative diseases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1835197-63-1
- 分子式: C13H22N2O3
- 分子量:254.33
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
|
NMDA Receptor |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Cerebellar granule neurone | EC50 |
10.68 μM
Compound: MN-05
|
Neuroprotective activity against glutamate-induced excitotoxicity in mouse primary cerebellar granule neurons assessed as increase in cell viability preincubated for 2 hrs followed by glutamate challenge measured after 24 hrs by MTT assay
Neuroprotective activity against glutamate-induced excitotoxicity in mouse primary cerebellar granule neurons assessed as increase in cell viability preincubated for 2 hrs followed by glutamate challenge measured after 24 hrs by MTT assay
|
[PMID: 30108699] |
MN-05 (0.1-100 μM; 24 h) potently protects primary cerebellar granule neurons against glutamate-induced injury, with an EC50 of 10.68 μM[1].
MN-05 (5-45 μM; 24 h) protects primary rat cortical neurons against glutamate-induced injury in vitro in a concentration-dependent manner[1].
MN-05 (5-15 μM; 5 min) inhibits glutamate-induced intracellular calcium influx in primary cortical neurons[1].
MN-05 (5-45 μM; 12 h) concentration-dependently inhibits the production of reactive oxygen/nitrogen species in primary cortical neurons induced by glutamate[1].
MN-05 (5-45 μM; 12 h) maintains mitochondrial membrane potential in a concentration-dependent manner and inhibits glutamate-induced mitochondrial dysfunction in primary cortical neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1835197-63-1
-
分子量 254.33
-
分子式 C13H22N2O3
-
SMILES
NC(C1)(CC(C2)(C3)CC)CC2CC13CO[N+]([O-])=O
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MN-05 関連分類
HY-126939 関連分類
Powered by Bioz