スルファメチゾール
Based on 2 publication(s) in Google Scholar
Sulfamethizole is a sulfathiazole antibiotic. Sulfamethizole inhibits the synthesis of folic acid and thymine, and selectively suppresses Photobacterium phosphoreum bioluminescence. Sulfamethizole exerts antibacterial activity against Escherichia coli-mediated urinary tract infections but no activity against sulII gene-positive Escherichia coli. Sulfamethizole is applicable for the research of urinary tract infections and Photobacterium phosphoreum bioluminescence mechanisms.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.76%
- CAS 番号: 144-82-1
- 分子式: C9H10N4O2S2
- 分子量:270.33
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Sulfamethizole
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | IC50 |
>300 μM
Compound: 2
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Cytotoxicity against human BxPC3 cells by MTT assay
Cytotoxicity against human BxPC3 cells by MTT assay
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[PMID: 21353784] |
Sulfamethizole (3×10-4-10-3 M; 5-14 h) does not reduce in vitro luciferase or flavin reductase activities in cell-free extracts from Photobacterium phosphoreum strain 496 after 5 h and 14 h of incubation, with over 90% of extractable specific enzyme activity retained at 5 h for both concentrations[1].
Sulfamethizole exhibits distinct in vitro MIC values against different type 1-fimbriated E. coli clinical isolates, with MICs of 128 μg/mL, 512 μg/mL, and > 2048 μg/mL for strains KMA-26883, UVI-203, and KMA-28523, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | Cmax | T1/2 | Urine Concentration |
|---|---|---|---|---|---|
| Mice[2] | 1250 μg | s.c. | 91 μg/mL | 26 min | 3276 μg/mL |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ssc-CF1 (female, weight 30 g, ascending urinary tract infection model)[2]
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Dosage:1.25 mg
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Administration:s.c.; twice daily; 3 days
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Result:Reduced bacterial counts in urine, bladder and kidneys compared to the control group for E. coli strain D (MIC 128 μg/mL).
Reduced bacterial counts in urine, bladder and kidneys compared to the control group for E. coli strain E (MIC 512 μg/mL).
Failed to reduce bacterial counts in urine, bladder or kidneys compared to the control group for E. coli strain F (MIC > 2048 μg/mL, sulII gene-positive).
化学情報
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CAS 番号 144-82-1
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性状 Solid
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分子量 270.33
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分子式 C9H10N4O2S2
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Color White to off-white
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SMILES
O=S(C1=CC=C(N)C=C1)(NC2=NN=C(C)S2)=O
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別名
Sulfamethizole
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (369.92 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.25 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (287 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Watanabe H, et al. Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta. 1990;1017(3):229-234. [Content Brief]
[2]. Kerrn MB, et al. Effects of sulfamethizole and amdinocillin against Escherichia coli strains (with various susceptibilities) in an ascending urinary tract infection mouse model. Antimicrob Agents Chemother. 2003 Mar;47(3):1002-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6992 mL | 18.4959 mL | 36.9918 mL | 92.4796 mL |
| 5 mM | 0.7398 mL | 3.6992 mL | 7.3984 mL | 18.4959 mL | |
| 10 mM | 0.3699 mL | 1.8496 mL | 3.6992 mL | 9.2480 mL | |
| 15 mM | 0.2466 mL | 1.2331 mL | 2.4661 mL | 6.1653 mL | |
| 20 mM | 0.1850 mL | 0.9248 mL | 1.8496 mL | 4.6240 mL | |
| 25 mM | 0.1480 mL | 0.7398 mL | 1.4797 mL | 3.6992 mL | |
| 30 mM | 0.1233 mL | 0.6165 mL | 1.2331 mL | 3.0827 mL | |
| 40 mM | 0.0925 mL | 0.4624 mL | 0.9248 mL | 2.3120 mL | |
| 50 mM | 0.0740 mL | 0.3699 mL | 0.7398 mL | 1.8496 mL | |
| 60 mM | 0.0617 mL | 0.3083 mL | 0.6165 mL | 1.5413 mL | |
| 80 mM | 0.0462 mL | 0.2312 mL | 0.4624 mL | 1.1560 mL | |
| 100 mM | 0.0370 mL | 0.1850 mL | 0.3699 mL | 0.9248 mL |
Sulfamethizole 関連分類
HY-B0333 関連分類
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