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製品番号: HY-100443A

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trans-PX20606

(別名: trans-PX-102)

3 Cited Publications

カスタマーレビュー

Based on 3 publication(s) in Google Scholar

PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC₅₀s of 32 and 34 nM for FXR in FRET and M1H assay, respectively.

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純度: 99.24%
CAS 番号: 1268244-85-4
分子式: C₂₉H₂₂Cl₃NO₄
分子量:554.85

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

trans-PX20606 構造式

CAS 番号: 1268244-85-4

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価格（税別）

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数量

Amount: USD 0.00

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
化学情報
Publications (3)
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

PX20606 trans racemate (PX-102 trans racemate) is a FXR agonist with EC₅₀s of 32 and 34 nM for FXR in FRET and M1H assay, respectively^[1].

IC₅₀ & Target

EC50: 32 nM (FXR in FRET assay), 34 nM (FXR in M1H assay)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	186 nM Compound: 7a	Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay	[PMID: 27268696]
HEK293	EC₅₀	47 nM Compound: 7b	Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay Agonist activity at C-terminal Gal4-tagged human FXR (187 to 472 residues) expressed in HEK-293 cells co-expressing pFRluc by mammalian one hybrid assay	[PMID: 27268696]

化学情報

CAS 番号 1268244-85-4
性状 Solid
分子量 554.85
分子式 C₂₉H₂₂Cl₃NO₄
Color White to off-white
SMILES

O=C(O)C1=CC=C([C@H]2[C@H](C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3Cl)C2)C=C1
別名

trans-PX-102
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (3)

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Journal Impact Factor

Arch Toxicol

Farnesoid X receptor (FXR) agonists induce hepatocellular apoptosis and impair hepatic functions via FXR/SHP pathway. [Abstract]

2022 Jun;96(6):1829-1843. PMID: 35267068
Biochem Pharmacol

Efficient screening and evaluation of MRGPRX2 antagonists based on AlphaFold 3. [Abstract]

2025 Oct 23:117451. PMID: 41138926
Biochem Pharmacol

FXR agonists for colorectal and liver cancers, as a stand-alone or in combination therapy. [Abstract]

2023 Jun:212:115570. PMID: 37119860

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (180.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8023 mL

9.0114 mL

18.0229 mL

5 mM

0.3605 mL

1.8023 mL

3.6046 mL

10 mM

0.1802 mL

0.9011 mL

1.8023 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kinzel O, et al. Novel substituted isoxazole FXR agonists with cyclopropyl, hydroxycyclobutyl and hydroxyazetidinyl linkers: Understanding and improving key determinants of pharmacological properties. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8023 mL	9.0114 mL	18.0229 mL	45.0572 mL
	5 mM	0.3605 mL	1.8023 mL	3.6046 mL	9.0114 mL
	10 mM	0.1802 mL	0.9011 mL	1.8023 mL	4.5057 mL
	15 mM	0.1202 mL	0.6008 mL	1.2015 mL	3.0038 mL
	20 mM	0.0901 mL	0.4506 mL	0.9011 mL	2.2529 mL
	25 mM	0.0721 mL	0.3605 mL	0.7209 mL	1.8023 mL
	30 mM	0.0601 mL	0.3004 mL	0.6008 mL	1.5019 mL
	40 mM	0.0451 mL	0.2253 mL	0.4506 mL	1.1264 mL
	50 mM	0.0360 mL	0.1802 mL	0.3605 mL	0.9011 mL
	60 mM	0.0300 mL	0.1502 mL	0.3004 mL	0.7510 mL
	80 mM	0.0225 mL	0.1126 mL	0.2253 mL	0.5632 mL
	100 mM	0.0180 mL	0.0901 mL	0.1802 mL	0.4506 mL

Keywords

trans-PX20606

3 Cited Publications

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trans-PX20606

Metabolism/Protease Compound Library

Clinical Compound Library

Autophagy Compound Library

Nuclear Receptor Compound Library

Metabolic Enzyme Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

MedChemExpress（MCE）の使用を引用している文献 trans-PX20606

生物活性

化学情報

Publications (3)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

trans-PX20606

Metabolism/Protease Compound Library

Clinical Compound Library

Autophagy Compound Library

Nuclear Receptor Compound Library

Metabolic Enzyme Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

MedChemExpress（MCE）の使用を引用している文献 trans-PX20606

生物活性

化学情報

Publications (3)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

trans-PX20606 関連分類

HY-100443A 関連分類