1. Metabolic Enzyme/Protease
  2. FXR

Fexaramine 

Cat. No.: HY-10912 Purity: 98.78%
Handling Instructions

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds.

For research use only. We do not sell to patients.

Fexaramine Chemical Structure

Fexaramine Chemical Structure

CAS No. : 574013-66-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. IC50 value: Target: in vitro: In vitro treatment of CDCA or fexaramine elevated the SHP transcript level and occupancy on secretin promoter [1]. Fexaramine significantly enhanced osteoblastic differentiation through the upregulation of Runx2 and enhanced extracellular signal-regulated kinase (ERK) and β-catenin signaling [2]. By mimicking this tissue-selective effect, the gut-restricted FXR agonist fexaramine (Fex) robustly induces enteric fibroblast growth factor 15 (FGF15), leading to alterations in BA composition, but does so without activating FXR target genes in the liver [3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0135 mL 10.0677 mL 20.1353 mL
5 mM 0.4027 mL 2.0135 mL 4.0271 mL
10 mM 0.2014 mL 1.0068 mL 2.0135 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

496.64

Formula

C₃₂H₃₆N₂O₃

CAS No.

574013-66-4

SMILES

CN(C)C1=CC=C(C2=CC=C(CN(C3=CC(/C=C/C(OC)=O)=CC=C3)C(C4CCCCC4)=O)C=C2)C=C1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 98.78%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Fexaramine
Cat. No.:
HY-10912
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Fexaramine

Cat. No.: HY-10912