XAX-162
XAX-162 is a highly selective sphingosine 1-phosphate receptor 2 (S1PR2) agonist with a human EC50 of 0.55 μM. XAX-162 does not activate other S1P receptors. XAX-162 exhibits noncompetitive inhibition of activity by S1PR2 antagonist JTE-013 (HY-100675).
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- CAS 番号: 883053-48-3
- 分子式: C16H15NO2S3
- 分子量:349.49
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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S1PR2 0.55 μM (EC50) |
XAX-162 (0.55 μM) activates S1PR2 in S1PR2 CRE-bla CHO cells with an EC50 of 0.55 μM, reaching a maximum activity 130% of that induced by 1 μM S1P[1].
XAX-162-mediated receptor activation is inhibited by JTE-013 (HY-100675) in a noncompetitive manner, with reduced response magnitude and right-shifted dose-response curves as JTE-013 concentration increases in S1PR2 CRE-bla CHO cells[1].
XAX-162 is highly selective for S1PR2, showing no agonist activity in cell-based assays for S1PR1, S1PR3, S1PR4, or S1PR5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 883053-48-3
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分子量 349.49
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分子式 C16H15NO2S3
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SMILES
CC(C=C1)=CC=C1SC2=CC=C(C3SCCS3)C=C2[N+]([O-])=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
XAX-162 関連分類
HY-182618 関連分類
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