ZG-10
ZG-10 (JNK-IN-2) is a JNK inhibitor, with IC50 values of 809 nM, 1140 nM and 709 nM for JNK1, JNK2, and JNK3, respectively. ZG-10 (JNK-IN-2) is a potential anti-SARS-CoV-2 agent.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1408077-04-2
- 分子式: C28H27N7O2
- 分子量:493.56
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
JNK1 809 nM (IC50) |
JNK2 1140 nM (IC50) |
JNK3 709 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
2.4 μM
Compound: 70
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Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation
Inhibition of JNK3-mediated c-jun phosphorylation in human A375 cells after 1 hr incubation
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[PMID: 25415535] |
| HeLa | IC50 |
0.704 μM
Compound: 70
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Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubation
Inhibition of JNK3-mediated c-jun phosphorylation in human HeLa cells after 1 hr incubation
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[PMID: 25415535] |
化学情報
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CAS 番号 1408077-04-2
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分子量 493.56
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分子式 C28H27N7O2
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SMILES
O=C(NC1=CC=C(C(NC2=CC(NC3=NC(C4=CN=CC=C4)=CC=N3)=CC=C2)=O)C=C1)/C=C/CN(C)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (264 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Tinghu Zhang, et al. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. [Content Brief]
[2]. Rui Zhang, et al. Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium. Bioengineered. 2022 Feb;13(2):2486-2497. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
ZG-10 関連分類
HY-112894 関連分類
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