AKR1C3 - aldo-keto reductase family 1 member C3 Gene

Also Known as DD3; DDX; PGFS; HAKRB; HAKRe; HA1753; HSD17B5; hluPGFS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8644

About AKR1C3

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,048,781-5,107,686 (from NCBI)

This gene has 11 transcripts (splice variants), 481 orthologues and 16 paralogues. Broad expression in duodenum (RPKM 122.7), gall bladder (RPKM 91.1) and 15 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. These Enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The Enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three Other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

AKR1C3 Products (3)

mRNA	Protein	Name
NM_001253908.2	NP_001240837.1	aldo-keto reductase family 1 member C3 isoform 2
NM_001253909.2	NP_001240838.1	aldo-keto reductase family 1 member C3 isoform 3
NM_003739.6	NP_003730.4	aldo-keto reductase family 1 member C3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	22170488	GOA
enables Delta4-3-oxosteroid 5beta-reductase activity	IDA IDA: Inferred from direct assay	16983398	GOA
enables aldo-keto reductase (NADPH) activity	IDA IDA: Inferred from direct assay	9792917	GOA
enables aldose reductase (NADPH) activity	IDA IDA: Inferred from direct assay	21232532	GOA
enables all-trans-retinol dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	21851338	GOA
enables androsterone dehydrogenase activity	IDA IDA: Inferred from direct assay	16983398	GOA
enables geranylgeranyl reductase activity	IDA IDA: Inferred from direct assay	21187079	GOA
enables ketoreductase activity	IDA IDA: Inferred from direct assay	19487289	GOA
enables ketosteroid monooxygenase activity	IDA IDA: Inferred from direct assay	21232532	GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	IDA IDA: Inferred from direct assay	19442656	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables retinal dehydrogenase activity	IDA IDA: Inferred from direct assay	21851338	GOA
enables testosterone dehydrogenase [NAD(P)+] activity	IDA IDA: Inferred from direct assay	16983398	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18508192	GOA
involved in cellular response to calcium ion	IDA IDA: Inferred from direct assay	22170488	GOA
involved in cellular response to corticosteroid stimulus	IDA IDA: Inferred from direct assay	19336506	GOA
involved in cellular response to jasmonic acid stimulus	IDA IDA: Inferred from direct assay	19487289	GOA
involved in cellular response to prostaglandin D stimulus	IDA IDA: Inferred from direct assay	18508192	GOA
involved in cellular response to prostaglandin stimulus	IDA IDA: Inferred from direct assay	22170488	GOA
involved in cellular response to starvation	IEP IEP: Inferred from expression pattern	18641923	GOA
involved in daunorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in doxorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in farnesol catabolic process	IDA IDA: Inferred from direct assay	21187079	GOA
involved in keratinocyte differentiation	IEP IEP: Inferred from expression pattern	22170488	GOA
involved in macromolecule metabolic process	IEP IEP: Inferred from expression pattern	18641923	GOA
involved in male gonad development	IEP IEP: Inferred from expression pattern	19942269	GOA
involved in negative regulation of retinoic acid biosynthetic process	IDA IDA: Inferred from direct assay	21851338	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18508192	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21851338	GOA
involved in positive regulation of endothelial cell apoptotic process	IDA IDA: Inferred from direct assay	19442656	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	18508192	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	19442656	GOA
involved in progesterone metabolic process	IDA IDA: Inferred from direct assay	21232532	GOA
involved in prostaglandin metabolic process	IDA IDA: Inferred from direct assay	9792917	GOA
involved in prostaglandin metabolic process	IEP IEP: Inferred from expression pattern	20036328	GOA
involved in regulation of retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	21851338	GOA
involved in regulation of testosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	19336506	GOA
involved in response to nutrient	IEP IEP: Inferred from expression pattern	19007764	GOA
involved in retinal metabolic process	IDA IDA: Inferred from direct assay	21851338	GOA
involved in steroid metabolic process	IEP IEP: Inferred from expression pattern	20036328	GOA
involved in testosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	16983398	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18574251	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18574251	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1C3 Protein Structure

Aldo_ket_red

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
aldo-keto reductase family 1 member C3	3-alpha hydroxysteroid dehydrogenase, type II

AKR1C3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AKR1C3	P42330	AKR1C4	Homo sapiens	P17516	Anti Tag CoIP	33961781
Intra	AKR1C3	P42330	AKR1C4	Homo sapiens	P17516	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AKR1C3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7604	AKR1C3 Protein, Human (HEK293, His)	P42330 (M1-Y323)	≥ 95%, as determined by reducing SDS-PAGE.

AKR1C3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82593	AKR1C3 Antibody (YA2338)	WB, ICC/IF, IP, FC	Human

Related Diseases

Diseases	Alias
Larynx Squamous Papilloma	Laryngeal Squamous Cell Papilloma
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
17-Beta Hydroxysteroid Dehydrogenase Iii Deficiency	17-Ksr Deficiency Neutral 17-Beta-Hydroxysteroid Oxidoreductase Deficiency Pseudohermaphroditism, Male, With Gynecomastia 17-Beta Hydroxysteroid Dehydrogenase 3 Deficiency Testosterone 17-Beta-Dehydrogenase Deficiency 17-Ketosteroid Reductase Deficiency Of Testis 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency 17-Ketoreductase Deficiency 17-Ketosteroidreductase Deficiency 46,Xy Disorder Of Sex Development Due To 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency Male Pseudohermaphroditism With Gynecomastia 17 Alpha Ksr Deficiency 17 Alpha Ketosteroid Reductase Deficiency Of Testis 17 Beta Hydroxysteroid Dehydrogenase Iii Deficiency Male Pseudoherma-Phroditism With Gynecomastia Neutral 17 Beta Hydroxysteroid Oxidoreductase Deficiency Male Pseudohermaphrodism With Gynecomastia MPH 17-Hydroxysteroid Dehydrogenase Deficiency
Lipoid Congenital Adrenal Hyperplasia	Congenital Adrenal Hyperplasia Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency Congenital Lipoid Adrenal Hyperplasia Lipoid Cah Lipoid Adrenal Hyperplasia Adrenal Hyperplasia 1 Cah Clah LCAH Adrenal Hyperplasia I Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism Congenital Adrenal Hyperplasia Lipoid Adrenal Hyperplasia, Congenital Congenital Adrenal Hyperplasia, Lipoid AH1 Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism Adrenal Hyperplasia Congenital Hyperplasia, Adrenal, Lipoid, Congenital Congenital Adrenogenital Disorders Associated With Enzyme Deficiency Congenital Adrenal Cortical Hyperplasia Congenital Adrenal Gland Hyperplasia Congenital Adrenogenital Syndrome Congenital Hyperadrenocorticism Congenital Adrenogenitalism Congenital Female Adrenal Pseudohermaphroditism
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Phase
HY-19903	ASP-9521	98.0%	Phase 2
HY-124573	(R)-Odafosfamide	98.52%	Phase 2
HY-149040	Odafosfamide	99.06%	Phase 2
HY-156701	BAY-1128688	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (51)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0376	Liquiritin		99.99%	Unkown
HY-150644	S07-2010		98.35%	Unkown
HY-107379	AKR1C3-IN-1		98.21%	Unkown
HY-138557	AKR1C3-IN-4		99.77%	Unkown
HY-152189	S19-1035		99.93%	Unkown
HY-W008567	N-Deschlorobenzoyl indomethacin		95.0%	Unkown
HY-N10361	Drupanin		99.35%	Unkown
HY-109154	Obafistat	Inhibitor	99.92%	Unkown
HY-155035	S07-1066		99.48%	Unkown
HY-D1342	Coumberol		99.99%	Unkown
HY-152188	AKR1C3-IN-9		99.77%	Unkown
HY-172314	ACHM-025		98.06%	Unkown
HY-W414731	N-(3-Methylphenyl)anthranilic acid		99.82%	Unkown
HY-163940	LX1		99.13%	Unkown
HY-171115	Pyrone-211		99.32%	Unkown
HY-116170	SN34037	Inhibitor	99.02%	Unkown
HY-176084	RJG-2051		99.42%	Unkown
HY-W024692	Indomethacin methylester		99.92%	Unkown
HY-19903R	ASP-9521 (Standard)		94.47%	Unkown
HY-W069545	(S)-1-Tetralol		99.75%	Unkown
HY-121656	AKR1C2/3-IN-2	Inhibitor	/	Unkown
HY-123732	CRT0083914		/	Unkown
HY-144749	AKR1C3-IN-5		/	Unkown
HY-146573	AKR1C3-IN-6		/	Unkown
HY-146574	AKR1C3-IN-7		/	Unkown
HY-146575	AKR1C3-IN-8		/	Unkown
HY-150646	S07-2009		/	Unkown
HY-150648	S07-2008		/	Unkown
HY-150649	S07-2005 (racemic)		/	Unkown
HY-150650	S07-2001		/	Unkown
HY-155502	AKR1C3-IN-10		/	Unkown
HY-157810	AKR1C3-IN-11		/	Unkown
HY-161839	AKR1C2/3-IN-1		/	Unkown
HY-163323	AKR1C3-IN-12		/	Unkown
HY-163609	PROTAC AKR1C3 degrader-1	Degrader	/	Unkown
HY-163610	AKR1C3-IN-13		/	Unkown
HY-163784	AKR1C3-IN-14		/	Unkown
HY-173132	AKR1Cs-IN-1		/	Unkown
HY-173453	AKR1C3-IN-15		/	Unkown
HY-180562	KARS-IN-1	Inhibitor	/	Unkown
HY-181542	SG-55		/	Unkown
HY-184699	AKR1C3-IN-16	Inhibitor	/	Unkown
HY-184927	S34-1035	Inhibitor	/	Unkown
HY-184928	S34-1040	Inhibitor	/	Unkown
HY-187527	AKR1C3-IN-17		/	Unkown
HY-N0376R	Liquiritin (Standard)		/	Unkown
HY-RS00536	AKR1C3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W706737	N-Deschlorobenzoyl indomethacin-d3		/	Unkown
HY-124432	CRT0093964	Inhibitor	/	Unkown
HY-163647	Lenalidomide-COCH-PEG2-azido		/	Unkown
HY-RS23044	Akr1c3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AKR1C3	RGD	RGD:708428
Others	AKR1C3	NCBI