AM-36
AM-36 is a neuroprotective agent with combined antioxidant and sodium channel blocking actions. AM-36 can inhibit cell apoptosis and ROS prodiction. AM-36 can reduce neuronal damage and DA release after middle cerebral artery occlusion in rats. AM-36 can be used for the researches of inflammation and neurological disease, such as stroke.
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- CAS No.: 199467-52-2
- 화학식: C27H39ClN2O2
- 분자량:459.06
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
AM-36 (0.01-10 μM) completely inhibits Veratridine (HY-N6691)-induced toxicity (IC50 = 1.5-1.9 μM) and inhibits apoptosis in cerebellar granule cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Middle cerebral artery occlusion (MCAO) rats[1]
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Dosage:6 mg/kg
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Administration:Intraperitoneally injection, 30, 60 and 180 mins after MCAO
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Result:Reduced cortical damage and neuronal damage.
Reduced Striatal damage treated with AM-36 at 180 mins.
Chemical Information
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CAS No. 199467-52-2
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분자량 459.06
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화학식 C27H39ClN2O2
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SMILES
ClC1=CC=C(C(CN2CCN(CC2)CC3=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C3)O)C=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Callaway JK, et al. Delayed treatment with AM-36, a novel neuroprotective agent, reduces neuronal damage after endothelin-1-induced middle cerebral artery occlusion in conscious rats. Stroke. 1999 Dec;30(12):2704-12; discussion 2712. [Content Brief]
[2]. Callaway JK, et al. Incorporation of sodium channel blocking and free radical scavenging activities into a single drug, AM-36, results in profound inhibition of neuronal apoptosis. Br J Pharmacol. 2001 Apr;132(8):1691-8. [Content Brief]
[3]. Callaway JK, et al. AM-36, a novel neuroprotective agent, profoundly reduces reactive oxygen species formation and dopamine release in the striatum of conscious rats after endothelin-1-induced middle cerebral artery occlusion. Neuropharmacology. 2003 May;44(6):787-800. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AM-36 Related Classifications
HY-114659 Related Classifications
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