HDAC3-IN-5
HDAC3-IN-5 (9c) is a HDAC3 selective inhibitor, with IC50 values of 4.2 nM, 1629 nM and 298.2 nM for HDAC3, HDAC2, HDAC1, respectively. HDAC3-IN-5 (9c) can effectively induce apoptosisin MV4-11 cells in vitro and reduce the expression of anti-apoptotic proteins, the development of HDAC3 selective inhibitors may serve as a potential lead compound to reverse Venetoclax resistance.
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- CAS No.: 3095232-95-1
- 화학식: C28H38N4O
- 분자량:446.63
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
HDAC3 4.2 nM (IC50) |
HDAC1 298.2 nM (IC50) |
HDAC2 1629 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| JeKo-1 | IC50 |
484 nM
Compound: 9c
|
Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human JeKo-1 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
|
[PMID: 39047608] |
| K562 | IC50 |
383 nM
Compound: 9c
|
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
|
[PMID: 39047608] |
| MV4-11 | IC50 |
315 nM
Compound: 9c
|
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 48 hrs by resazurin staining based assay
|
[PMID: 39047608] |
Chemical Information
-
CAS No. 3095232-95-1
-
분자량 446.63
-
화학식 C28H38N4O
-
SMILES
O=C(NNCCC)/C=C/C1=CC=C(CN(CCCC)CCC2=C(C)NC3=C2C=CC=C3)C=C1
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)