HDAC6-IN-75

HDAC6-IN-75 (compound 3a) (0.0032-50 μM; 24-72 h) exhibits time-dependent cytotoxicity in glioma cell lines, with GI₅₀ values ranging from 0.8 μM to 5.3 μM after 72 h of incubation, and induces total growth inhibition in HOG, T98G, and U251MG cells at 72 h^[1].
HDAC6-IN-75 (compound 3a) (34.0 μM HOG, 16.2 μM T98G, 50 μM U87MG, 28.9 μM U251MG; 24 h) increases acetyl-α-tubulin levels in all four tested glioma cell lines and acetyl-histone H3 levels in HOG, T98G, and U251MG cells after 24 h of treatment, consistent with its HDAC6 inhibitory activity and concurrent class I HDAC inhibition at cellular concentrations^[1].
HDAC6-IN-75 (compound 3a) (34.0 μM HOG, 16.2 μM T98G, 50 μM U87MG, 28.9 μM U251MG; 24 h) induces DNA fragmentation (SubG1 accumulation) in T98G and U251MG cells, and modulates cell cycle progression by shifting populations from G0/G1 to G2/M in U87MG, U251MG, and HOG cells after 24 h of treatment^[1].
HDAC6-IN-75 (compound 3a) (34.0 μM HOG, 16.2 μM T98G, 50 μM U87MG, 28.9 μM U251MG; 24 h) reduces viability and induces late apoptosis and necrosis in HOG and U251MG glioma cells after 24 h of treatment^[1].
HDAC6-IN-75 (compound 3a) (0.0032-50 μM; 72 h) exhibits cytotoxicity against glioblastoma stem cells, with an IC₅₀ of 3.725 μM in proneural GSC23 cells and 12.90 μM in mesenchymal GG16 cells after 72 h of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.