Hymeglusin
Based on 1 Customer Validation
Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme.
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- Purity: 99.30%
- CAS No.: 29066-42-0
- 화학식: C18H28O5
- 분자량:324.41
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보관:
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
Hymeglusin inhibits dengue type 2 (DEN-2) New Guinea C (NGC) live virus replication in K562 cells. The therapeutic index (CC50/IC50) of Hymeglusin is 11. The EC50 of Hymeglusin in K562 cells is 4.5 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 29066-42-0
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Appearance Solid
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분자량 324.41
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화학식 C18H28O5
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Color White to off-white
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SMILES
O=C(O)/C=C(C)/C=C(C)/C[C@H](C)CCCC[C@H]([C@H]1CO)OC1=O
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Synonyms
F-244; 1233A; L-659699
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
용액&용해도
DMSO : ≥ 25 mg/mL (77.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Rothwell C, et al. Cholesterol biosynthesis modulation regulates dengue viral replication. Virology. 2009 Jun 20;389(1-2):18-19. [Content Brief]
[2]. Greenspan MD, et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7488-92. [Content Brief]
[3]. Tomoda H, et al. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636(1):22-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0825 mL | 15.4126 mL | 30.8252 mL | 77.0630 mL |
| 5 mM | 0.6165 mL | 3.0825 mL | 6.1650 mL | 15.4126 mL | |
| 10 mM | 0.3083 mL | 1.5413 mL | 3.0825 mL | 7.7063 mL | |
| 15 mM | 0.2055 mL | 1.0275 mL | 2.0550 mL | 5.1375 mL | |
| 20 mM | 0.1541 mL | 0.7706 mL | 1.5413 mL | 3.8531 mL | |
| 25 mM | 0.1233 mL | 0.6165 mL | 1.2330 mL | 3.0825 mL | |
| 30 mM | 0.1028 mL | 0.5138 mL | 1.0275 mL | 2.5688 mL | |
| 40 mM | 0.0771 mL | 0.3853 mL | 0.7706 mL | 1.9266 mL | |
| 50 mM | 0.0617 mL | 0.3083 mL | 0.6165 mL | 1.5413 mL | |
| 60 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2844 mL |
Hymeglusin Related Classifications
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