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United States

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Cat. No.: HY-177784

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iDeg-3

iDeg-3 is a potent IDO1 molecular glue degrader. iDeg-3 binds to apo-IDO1 and alters its C-terminal conformation, promoting CRL2-KLHDC3 E3 ligase-mediated ubiquitination and degradation of IDO1. iDeg-3 is suitable for cancer-related research.

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화학식: C₃₁H₃₈N₂O₄S
분자량:534.71

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

iDeg-3 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

IDO1

All Indoleamine 2,3-Dioxygenase (IDO) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	46 nM	Inhibition of IDO1-mediated kynurenine formation in IFN-γ-stimulated human BxPC3 cells incubated for 48 h by Kyn assay. Inhibition of IDO1-mediated kynurenine formation in IFN-γ-stimulated human BxPC3 cells incubated for 48 h by Kyn assay.	41501556

In Vitro

iDeg-3 (48 h) potently inhibits Kyn production in IFN-γ (HY-P7025)-stimulated BxPC3 cells, with an IC₅₀ of 46 nM^[1].
iDeg-3 (1-3.33 μM; 24 h) reduces IDO1 protein levels by 62% in IFN-γ-stimulated BxPC3 cells and decreases IDO1 reporter protein levels in KBM7 cells^[1].
iDeg-3 (50 μM; 3 h) stabilizes recombinant rhIDO1 protein in in vitro biochemical assays (nanoDSF)^[1].
iDeg-3 (5 μM; 2.5 h) enhances the interaction between IDO1 and KLHDC3 in HEK293T cells (expressing TurboID-IDO1)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

IFN-γ-stimulated BxPC3 cells
Concentration:

3.33 μM
Incubation Time:

24 h
Result:

Reduced IDO1 protein levels by 62% compared to vehicle control.

Chemical Information

분자량 534.71
화학식 C₃₁H₃₈N₂O₄S
SMILES

C#CC1=CC=C(C=C1)NC(OC[C@@]23[C@H](C[C@@H]4C[C@]2([H])CN(C3)S(C5=CC=C(C(C)(C)C)C=C5)(=O)=O)C4(C)C)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hennes E, et al. Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3. Nature chemistry. 2026 Mar;18(3):585-596.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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