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Cat. No.: HY-129287

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JMV 3008

JMV 3008 is a GHS-R1a antagonist with an IC₅₀ of 5.6 nM. JMV 3008 can be used in the research of diseases such as diabetes and obesity.

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CAS No.: 925239-09-4
화학식: C₃₆H₃₉N₇O₃
분자량:617.74

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

JMV 3008 Chemical Structure

CAS No.: 925239-09-4

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

JMV 3008 is a GHS-R1a antagonist with an IC₅₀ of 5.6 nM. JMV 3008 can be used in the research of diseases such as diabetes and obesity^[1].

IC₅₀ & Target^[1]

GHSR1a

5.6 nM (IC₅₀)

All GHSR Isoforms :

GHSR1a

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	5.6 nM Compound: 2, JMV 3008	Antagonist activity at mouse GSH-R1a receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced calcium mobilization after 5 mins by FLIPR assay Antagonist activity at mouse GSH-R1a receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced calcium mobilization after 5 mins by FLIPR assay	[PMID: 22342626]
LLC-PK1	IC₅₀	5.6 nM Compound: JMV 3008	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	[PMID: 18193826]

Chemical Information

CAS No. 925239-09-4
분자량 617.74
화학식 C₃₆H₃₉N₇O₃
SMILES

O=C([C@H]1NCCC1)N[C@@H](C2=NN=C(CCC3=CNC4=C3C=CC=C4)N2CC5=CC=C(OC)C=C5OC)CC6=CNC7=C6C=CC=C7
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hanrahan P, et al. Substituted azaquinazolinones as modulators of GHSr-1a for the treatment of type II diabetes and obesity. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2271-8. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

JMV 3008

All GHSR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

JMV 3008 Related Classifications

HY-129287 Related Classifications