MSA Protein
Based on 1 Customer Validation
MSA Protein (Mouse Serum Albumin) is most abundant protein in plasma, which leaks into the brain parenchyma when the blood-brain barrier (BBB) is impaired. Mouse Serum Albumin induces astrocytes to A1 phenotype to remarkably increase levels of Elovl1. Mouse Serum Albumin promotes VLSFAs secretion and causes neuronal lippoapoptosis through endoplasmic reticulum stress response pathway. MSA-activated microglia triggeres remarkable tau phosphorylation at multiple sites (Ser202/Thr205) through NLRP3 inflammasome pathway. Mouse Serum Albumin decreases the spatial learning and memory abilities in mice. Mouse Serum Albumin can be used for the study of neurodegenerative diseases like Alzheimer’s disease (AD) and frontotemporal dementia (FTD).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 95%
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
MSA Protein (7 uM, 48 h) significantly reduces average branch length, number of end-point voxels and branches of primary neurons[1].
MSA Protein (7 uM, 24 h) upregulates Elovl1 mRNA and protein levels in primary astrocyte [1].
MSA Protein (7 uM, 48 h) induces significant neuronal apoptosis, with increased Tunel-positive cells in primary neurons[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:2-month-old female C57BL/6J mice[1]
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Dosage:1 μL per injection
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Administration:Intracerebroventricular injection every 4 days for 16 days
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Result:Achieved impaired spatial learning and memory.
Induced increased neuronal apoptosis in hippocampus and neuroinflammation (enhanced microgliosis/astrogliosis, upregulated brain levels of IL-1β, IL-6 and TNF-α).
Promoted tau phosphorylation (increased p-tau at Ser202/Thr205) via activating NLRP3 inflammasome (upregulated NLRP3, ASC, cleaved caspase-1) and downstream IL-1β/IL-18-GSK3β/CaMKIIα pathway.
Downregulated M0 phenotype and phagocytosis-related genes and upregulated MGnD and inflammation-related genes in microglia.
Upregulated A1 astrocyte and inflammation genes and activated VLSFAs elongation pathway in astrocytes.
Downregulated mitochondrial β-oxidation, electron transport and GABA transmission-related genes in neurons.
Chemical Information
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Appearance Solid
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Color White to light yellow
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SMILES
[Mouse Serum Albumin]
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Synonyms
Mouse Serum Albumin
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MSA Protein Related Classifications
HY-NP0204 Related Classifications
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