MPiN
MPiN is a KV1.3 potassium channel inhibitor. The IC50 values of MPiN for inhibiting Kv1.3 currents are 1.1 μM (at -90 mV) and 0.6 μM (at -35 mV). MPiN exhibits in vivo efficacy in a mouse psoriasis model. MPiN can be used for the research of psoriasis.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 108975-37-7
- 화학식: C17H21NO
- 분자량:255.35
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
제품 설명
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
1.1 μM
|
Inhibition of human KV1.3 channel currents in HEK293T cells held at -90 mV (predominantly closed state) assessed via whole-cell patch-clamp electrophysiology assay with acute perfusion of MPiN.
Inhibition of human KV1.3 channel currents in HEK293T cells held at -90 mV (predominantly closed state) assessed via whole-cell patch-clamp electrophysiology assay with acute perfusion of MPiN.
|
2026.07.06.736759 |
| HEK-293T | IC50 |
0.6 μM
|
Inhibition of human KV1.3 channel currents in HEK293T cells held at -35 mV (predominantly inactivated state) assessed via whole-cell patch-clamp electrophysiology assay with acute perfusion of MPiN.
Inhibition of human KV1.3 channel currents in HEK293T cells held at -35 mV (predominantly inactivated state) assessed via whole-cell patch-clamp electrophysiology assay with acute perfusion of MPiN.
|
2026.07.06.736759 |
In Vitro
MPiN (10 μM) potently and reversibly inhibits human KV1.3 channels expressed in HEK293T cells, with higher inhibitory potency for inactivated channels (IC50 = 0.6 μM) than for closed channels (IC50 = 1.1 μM)[1].
MPiN (10 μM; 5 min) selectively inhibits human KV1.3 channels expressed in HEK293T cells, and acts only after the channels open[1].
MPiN (5-20 μM) allosterically promotes voltage sensor activation of human KV1.3 channels expressed in HEK293T cells, while inhibiting channel currents and inducing a hyperpolarizing shift in the activation curve without altering steady-state inactivation[1].
MPiN binds to a novel extracellular pocket formed by the PP1-PP2 turret loop, pore helix, and outer S5/S6 helices on human KV1.3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:BALB/c (male, 5-6 weeks old, imiquimod-induced psoriasis model)[1]
-
Dosage:25 mg/kg
-
Administration:i.p.; once daily for 10 days
-
Result:Significantly reduced total Psoriasis Area and Severity Index scores.
Reduced spleen index.
Suppressed serum TNF-α levels.
Attenuated epidermal thickening.
Chemical Information
-
CAS No. 108975-37-7
-
분자량 255.35
-
화학식 C17H21NO
-
SMILES
OC1=C(CN2CCCCC2C)C3=CC=CC=C3C=C1
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MPiN Related Classifications
HY-187707 Related Classifications
Powered by Bioz