S 8308

S 8308 (CV 2961) is a specific competitive angiotensin II receptor antagonist that inhibits the binding of radioligands, with an IC₅₀ of 15 μM in rat adrenal cortex microsomes and an IC₅₀ of 4.5 μM in rat aortic smooth muscle cells ^[3].
S 8308 inhibits the binding of ³H-AII to rat adrenal cortex microsomes with an IC₅₀ of 15 μM, and is a weak angiotensin II receptor antagonist^[6].
S 8308 (60 min) competitively inhibits the binding of angiotensin II to its receptor in rat adrenal cortex microsomes, with an IC₅₀ of 15 μM^[1].
S 8308 (30 min) competitively inhibits the binding of angiotensin II to its receptors on cultured rat aortic smooth muscle cells, with an IC₅₀ of 4.5 μM^[1].
S 8308 (1-30 µM; 15 min) inhibits angiotensin II-induced ⁴⁵Ca²⁺ influx in rat aortic rings in a concentration-dependent manner, with an IC₅₀ of 7 μM, and does not affect norepinephrine- or KCl-induced influx ^[1].
S 8308 (3-100 μM) competitively inhibits angiotensin II-induced contraction of isolated rabbit aortic strips, with a pA₂ value of 5.74, and does not affect the contractions induced by norepinephrine or KCl ^[1].
S 8308 (up to 100 μM) does not inhibit rabbit angiotensin-converting enzyme or rat renin activity^[2].
S 8308 is a non-selective ligand that binds with equal affinity to the AT₁ and AT₂ angiotensin II receptor subtypes in rat adrenal cortical tissue^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.