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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
Tango
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "Tango" in MCE Product Catalog:
1
1 Cited Publications
Target:
연구분야:
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM .
Synonyms: STK-001 sodium
Target:
연구분야:
Zorevunersen sodium is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen sodium increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen sodium restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen sodium can be used for research on Dravet syndrome .
Target:
연구분야:
2-Linoleoyl glycerol (2-Monolinolein) is a partial CB1 receptor agonist with a pEC50 of 4.781. 2-Linoleoyl glycerol activates the hCB1 receptor. 2-Linoleoyl glycerol does not induce an increase in intracellular free Ca 2+. 2-Linoleoyl glycerol can be used in the research of neurological disorders .
Cat. No.: HY-148410
CAS No.: 2415330-04-8
Synonyms: STK-001
Target:
연구분야:
Zorevunersen is an antisense oligonucleotide targeting the Scn1a gene based on TANGO technology. Zorevunersen increases Scn1a mRNA transcripts and elevates the expression level of NaV1.1 protein. Zorevunersen restores the excitability of PV interneurons, thereby reducing seizures and prolonging survival in mice. Zorevunersen can be used for research on Dravet syndrome .
Target:
(R,R)-CXCR2-IN-2 (compound 67), diastereoisomer of CXCR2-IN-2 (compound 68) (HY-120878), is a CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively .
Cat. No.: HY-164970
Target:
연구분야:
TANGO1-L Human scramble negative control is the scrambled negative control for TANGO1-L small interfering RNA.
Cat. No.: HY-RS14196
Target:
연구분야:
TANGO2 Human Pre-designed siRNA Set A contains three designed siRNAs for TANGO2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS08421
Target:
연구분야:
MIA3 Human Pre-designed siRNA Set A contains three designed siRNAs for MIA3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01011
Target:
연구분야:
ARNT Human Pre-designed siRNA Set A contains three designed siRNAs for ARNT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-163345
CAS No.: 1448808-50-1
Target:
연구분야:
5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment .
Cat. No.: HY-183578
Target:
연구분야:
TYY-31 is an orally active, selective S1PR1 agonist with an EC50 of 1.13 pM. TYY-31 promotes the phosphorylation of ERK1/2. TYY-31 exerts anti-inflammatory and immunosuppressive effects, ameliorates DSS-induced colitis in mice, and reduces peripheral blood lymphocyte counts in mice in a dose-dependent manner. TYY-31 can be used for the research of ulcerative colitis .
Cat. No.: HY-184208
CAS No.: 1863967-01-4
Target:
연구분야:
MCL-524 is a highly selective full agonist of the dopamine D2 receptor with a Kd value of 1.34 nM. MCL-524 specifically binds to the high-affinity state of the dopamine D2 receptor; this binding is abolished by guanylylimidodiphosphate, and it can distinguish between D2 high and D2 low sites. MCL-524 is applicable to research related to Parkinson's disease and schizophrenia .
Cat. No.: HY-P77255
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TPST1; Transport And Golgi Organization 13 Homolog A (Drosophila); Tyrosylprotein Sulfotransferase 1; Transport And Golgi Organization 13 Homolog A; Tango13A; Protein-Tyrosine Sulfotransferase; Protein-Tyrosine Sulfotransferase 1; Uncharacterized Protein
Species:
Human
Source:
HEK293
Cat. No.: HY-183773
Target:
연구분야:
KOR agonist-9 is a selective kappa opioid receptor (KOR) agonist with an EC50 of 1.41 nM. KOR agonist-9 exhibits >125-fold selectivity over μ/δ-opioid receptors. KOR agonist-9 antinociceptive and antipruritic effects in mice. KOR agonist-9 can be used for the research of pain, pruritus .
Cat. No.: HY-P71577
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EIF3M; Transport And Golgi Organization 7 Homolog (Drosophila); Prev. PCID1; Transport And Golgi Organization 7 Homolog; Tango7; Dendritic Cell Protein; Hfl-B5; B5 Receptor; GA17; HFL-B5; PCI Domain Containing 1 (Herpesvirus Entry Mediator); HFLB5; PCI Do
Species:
Human
Source:
E. coli
Cat. No.: HY-P85914
Synonyms: 90K; 90K MAC 2 BP; Basement membrane autoantigen p105; BTBD17B; Galectin 3 binding protein; Galectin-3-binding protein; L3 antigen; Lectin galactoside binding soluble 3 binding protein; Lectin galactoside-binding soluble 3-binding protein; LG3BP_HUMAN; LGALS3BP; M2BP; Mac 2 binding protein; Mac 2 BP; Mac-2 BP; Mac-2-binding protein; Mac2 BP; MAC2BP; Serum protein 90K; Tango10B; Transport and golgi organization 10 homolog B; Tumor associated antigen 90K; Tumor-associated antigen 90K
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
