Vialinin A
Based on 2 publication(s) in Google Scholar
Vialinin A (Terrestrin A) is a p-terphenyl compound that can be derived from a Chinese edible mushroom. Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4) and has anti-inflammatory and antioxidant properties. Vialinin A can alleviate cerebral ischaemia-reperfusion injury-induced neurological deficits and neuronal apoptosis. Vialinin A promotes activation of Keap1-Nrf2-ARE signaling pathway and increases the protein degradation of Keap1. Vialinin A possesses various pharmacological activities in cancer, Kawasaki disease, asthma, and pathological scarring. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A can be studied in reseach for autoimmune diseases, cancer and ischaemic stroke.
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- Purity: 99.90%
- CAS No.: 858134-23-3
- 화학식: C34H26O8
- 분자량:562.57
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Vialinin A
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
7 μM
Compound: Vialinin A
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Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs
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[PMID: 35901638] |
| Mast cell | IC50 |
0.04 nM
Compound: Vialinin A
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Inhibition of TNF-alpha production in mouse bone marrow-derived mast cells measured after 15 mins by ELISA
Inhibition of TNF-alpha production in mouse bone marrow-derived mast cells measured after 15 mins by ELISA
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[PMID: 27491710] |
| RBL-2H3 | IC50 |
0.09 nM
Compound: 1
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Inhibition of TNF-alpha production in rat RBL2H3 cells after 16 hrs by ELISA
Inhibition of TNF-alpha production in rat RBL2H3 cells after 16 hrs by ELISA
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[PMID: 23791076] |
| RBL-2H3 | IC50 |
0.09 nM
Compound: 2
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Inhibition of DNP-BSA-stimulated TNF-alpha production in rat RBL2H3 cells preincubated for 15 mins followed by DNP-BSA addition measured after 3 hrs by ELISA
Inhibition of DNP-BSA-stimulated TNF-alpha production in rat RBL2H3 cells preincubated for 15 mins followed by DNP-BSA addition measured after 3 hrs by ELISA
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[PMID: 24679673] |
| RBL-2H3 | IC50 |
0.09 nM
Compound: Vialinin A
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Inhibition of TNF-alpha production in antigen-stimulated rat RBL2H3 cells measured after 15 mins by ELISA
Inhibition of TNF-alpha production in antigen-stimulated rat RBL2H3 cells measured after 15 mins by ELISA
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[PMID: 27491710] |
| RBL-2H3 | IC50 |
0.25 nM
Compound: 2
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Inhibition of TNF-alpha production in rat RBL2H3 cells
Inhibition of TNF-alpha production in rat RBL2H3 cells
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[PMID: 24679673] |
| RBL-2H3 | IC50 |
20 pM
Compound: Vialinin A
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Inhibition of TNF-alpha production in rat RBL-2H3 cells
Inhibition of TNF-alpha production in rat RBL-2H3 cells
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[PMID: 35901638] |
| RBL-2H3 | IC50 |
90 pM
Compound: 1
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Antiinflammatory activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced TNF-alpha production preincubated for 15 mins prior DNP-BSA challenge measured after 30 mins by ELISA
Antiinflammatory activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced TNF-alpha production preincubated for 15 mins prior DNP-BSA challenge measured after 30 mins by ELISA
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[PMID: 22410084] |
Vialinin A (2 mg/kg, lateral ventricular injection, single dose) exhibits significant cognitive improvements compared to the vehicle group in C57BL/6JNifdc mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57BL/6JNifdc mice[2]
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Dosage:1, 2, 5 mg/kg
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Administration:Lateral ventricular injection
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Result:Mitigated infarct volume after middle cerebral artery occlusion (MCAO) and reduced the cerebral oedema with 2 and 5 mg/kg.
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Animal Model:Male C57BL/6JNifdc mice[2]
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Dosage:2 mg/kg
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Administration:Lateral ventricular injection
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Result:Exhibited significant cognitive improvements.
Alleviated neuronal apoptosis following cerebral ischaemic injury.
Significantly enhanced the levels of antioxidant factors, while reducing prooxidative factors.
Enhanced the activation of Keap1-Nrf2-ARE signaling.
Chemical Information
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CAS No. 858134-23-3
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Appearance Solid
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분자량 562.57
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화학식 C34H26O8
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Color White to light brown
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SMILES
O=C(CC1=CC=CC=C1)OC2=C(C(C3=CC=C(C=C3)O)=C(C(O)=C2C4=CC=C(O)C=C4)O)OC(CC5=CC=CC=C5)=O
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Synonyms
Terrestrin A
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Rep
Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X. [Abstract]2024 May 24;43(6):114248. PMID: 38795350 -
Pediatr Res
Kawasaki disease: ubiquitin-specific protease 5 promotes endothelial inflammation via TNFα-mediated signaling. [Abstract]2023 Jun;93(7):1883-1890. PMID: 36329225
용액&용해도
DMSO : 100 mg/mL (177.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ji-Kai Liu, et al. Natural terphenyls: developments since 1877. Chem Rev. 2006 Jun;106(6):2209-23. [Content Brief]
[2]. Jie Xu, et al. Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling.J Cell Mol Med. 2021 Jan;25(2):1140-1150. [Content Brief]
[3]. Himangshu Sonowal,et al. Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo. Oxid Med Cell Longev. 2018 Feb 6;2018:1052102. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7776 mL | 8.8878 mL | 17.7756 mL | 44.4389 mL |
| 5 mM | 0.3555 mL | 1.7776 mL | 3.5551 mL | 8.8878 mL | |
| 10 mM | 0.1778 mL | 0.8888 mL | 1.7776 mL | 4.4439 mL | |
| 15 mM | 0.1185 mL | 0.5925 mL | 1.1850 mL | 2.9626 mL | |
| 20 mM | 0.0889 mL | 0.4444 mL | 0.8888 mL | 2.2219 mL | |
| 25 mM | 0.0711 mL | 0.3555 mL | 0.7110 mL | 1.7776 mL | |
| 30 mM | 0.0593 mL | 0.2963 mL | 0.5925 mL | 1.4813 mL | |
| 40 mM | 0.0444 mL | 0.2222 mL | 0.4444 mL | 1.1110 mL | |
| 50 mM | 0.0356 mL | 0.1778 mL | 0.3555 mL | 0.8888 mL | |
| 60 mM | 0.0296 mL | 0.1481 mL | 0.2963 mL | 0.7406 mL | |
| 80 mM | 0.0222 mL | 0.1111 mL | 0.2222 mL | 0.5555 mL | |
| 100 mM | 0.0178 mL | 0.0889 mL | 0.1778 mL | 0.4444 mL |
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