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Cat. No.: HY-163031

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MAO-B-IN-28

MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC₅₀ of 1.9±0.5 nM. MAO-B-IN-28 can be used as a candidate for neurodegenerative diseases research.

For research use only. We do not sell to patients.

CAS No.: 3028096-72-9
Formula: C₁₉H₁₀F₃NO₄S
Molecular Weight:405.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

MAO-B-IN-28 Chemical Structure

CAS No.: 3028096-72-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC₅₀ of 1.9±0.5 nM. MAO-B-IN-28 can be used as a candidate for neurodegenerative diseases research^[1].

IC₅₀ & Target

monoamine oxidase B (MAO-B) IC50: 1.9±0.5 nM^[1]

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	21.38 μM Compound: 10e	Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37992521]
HepG2	IC₅₀	83.16 μM Compound: 10e	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37992521]
MCF7	IC₅₀	5.816 μM Compound: 10e	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37992521]
MGC-803	IC₅₀	39.64 μM Compound: 10e	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 37992521]

In Vitro

MAO-B-IN-28 (0.5-128 μM, 24 h) exhibits good cytotoxic effect on MCF-7 cells while having no remarkable cytotoxicity for MGC-803, HCT-116 and HepG2. MAO-B-IN-28 (0.5, 4 μM, 24 h) shows no cytotoxicity in both differentiated SH-SY5Y cells and HVSMC cells^[1].
MAO-B-IN-28 (2, 4 μM, 24 h) doesn't cause an increase in ROS levels and doesn't cause oxidative damage to differentiated SH-SY5Y cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

MCF-7, MGC-803, HCT-116 and HepG2
Concentration:

0.5, 1, 2, 4, 8, 16, 32, 64, 128 μM
Incubation Time:

24 h
Result:

Exhibited cytotoxicity IC₅₀s (μM) of 5.816, 21.38, 83.16, 39.64 for MCF-7, HCT-116, HepG2 and MGC-803 cells, respectively.

Chemical Information

CAS No. 3028096-72-9
Molecular Weight 405.35
Formula C₁₉H₁₀F₃NO₄S
SMILES

O=C(C1=C2C=CC=C1)C(C3=CC(C4=CC=CC(C(F)(F)F)=C4)=NO3)=CS2(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pengbing Mi, et al. Discovery of C-3 isoxazole substituted thiochromone S,S-dioxide derivatives as potent and selective inhibitors for monoamine oxidase B (MAO-B). European Journal of Medicinal Chemistry. 2024，263，115956. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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MAO-B-IN-28

All Monoamine Oxidase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

MAO-B-IN-28 Related Classifications

HY-163031 Related Classifications