2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-28

MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 of 1.9±0.5 nM. MAO-B-IN-28 can be used as a candidate for neurodegenerative diseases research.

For research use only. We do not sell to patients.

MAO-B-IN-28

MAO-B-IN-28 Chemical Structure

CAS No. : 3028096-72-9

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MAO-B-IN-28 Related Antibodies

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Description

MAO-B-IN-28 (compound 10e) is a potent hMAO-B inhibitor with an IC50 of 1.9±0.5 nM. MAO-B-IN-28 can be used as a candidate for neurodegenerative diseases research[1].

IC50 & Target

monoamine oxidase B (MAO-B) IC50: 1.9±0.5 nM[1]
Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
21.38 μM
Compound: 10e
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 37992521]
HepG2 IC50
83.16 μM
Compound: 10e
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 37992521]
MCF7 IC50
5.816 μM
Compound: 10e
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 37992521]
MGC-803 IC50
39.64 μM
Compound: 10e
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 37992521]
In Vitro

MAO-B-IN-28 (0.5-128 μM, 24 h) exhibits good cytotoxic effect on MCF-7 cells while having no remarkable cytotoxicity for MGC-803, HCT-116 and HepG2. MAO-B-IN-28 (0.5, 4 μM, 24 h) shows no cytotoxicity in both differentiated SH-SY5Y cells and HVSMC cells[1].
MAO-B-IN-28 (2, 4 μM, 24 h) doesn't cause an increase in ROS levels and doesn't cause oxidative damage to differentiated SH-SY5Y cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-28 Related Antibodies

Cell Viability Assay[1]

Cell Line: MCF-7, MGC-803, HCT-116 and HepG2
Concentration: 0.5, 1, 2, 4, 8, 16, 32, 64, 128 μM
Incubation Time: 24 h
Result: Exhibited cytotoxicity IC50s (μM) of 5.816, 21.38, 83.16, 39.64 for MCF-7, HCT-116, HepG2 and MGC-803 cells, respectively.
Molecular Weight

405.35

Formula

C19H10F3NO4S
CAS No.
SMILES

O=C(C1=C2C=CC=C1)C(C3=CC(C4=CC=CC(C(F)(F)F)=C4)=NO3)=CS2(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-B-IN-28 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-283028096-72-9Monoamine OxidaseMAOHVSMCMCF-7HCT-116HepG2MGC-80SH-SY5YHuman monoamine oxidase BinhibitorThiochromoneneurodegenerative diseaseInhibitorinhibit

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