Nortriterpene lactones from the fruits of Schisandra arisanensis
- J Nat Prod. 2010 Jul 23;73(7):1228-33. doi: 10.1021/np100048h.
- 1. School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road Sec. 1, Taipei 100, Taiwan, Republic of China.
Fractionation of an acetone Extract from the fruits of Schisandra arisanensis afforded five new nortriterpene Lactones, compounds 1-5, together with four known compounds, schindilactones D and E (6 and 7) and preschisanartanins A and B (8 and 9). Compound 1, a wuweiziartane-type nortriterpenoid, possesses a new type of fused ring system with a gamma-lactone ring between C-15 and C-17. Compounds 2, 6, and 7 may be categorized as schisanartane-type nortriterpenoids and compounds 3-5, 8, and 9 as preschisanartane-type nortriterpenoids. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopic data interpretation. The structure and relative configuration of 3 were supported by single-crystal X-ray diffraction analysis. The Antiviral activity against HSV-1 and inhibitory effects on superoxide anion generation and Elastase release by human neutrophils in response to FMLP/CB of compounds 1-9 were evaluated.