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Cat. No.: HY-P12140

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MyHC‐α 614‐629

MyHC-α 614-629 is a specific polypeptide fragment of cardiac α-myosin heavy chain. MyHC-α 614-629 acts as an autoantigen to induce CD4⁺ T cell-mediated autoimmune responses in the immune system, thereby causing inflammatory infiltration and damage to myocardial tissue. MyHC-α 614-629 is applicable to the research of experimental autoimmune myocarditis.

For research use only. We do not sell to patients.

CAS No.: 245092-22-2
Formula: C₇₉H₁₂₅N₁₇O₂₅S
Molecular Weight:1745.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MyHC‐α 614‐629 Chemical Structure

CAS No.: 245092-22-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

All Myosin Isoforms :

MLCK

In Vivo

MyHC-α 614-629 (s.c.; once weekly for two doses; 21 days) induces experimental autoimmune myocarditis (EAM) in Balb/c mice, leading to initial left ventricular dilation followed by ventricular hypertrophy, without causing significant left ventricular systolic dysfunction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 245092-22-2
Molecular Weight 1745.00
Formula C₇₉H₁₂₅N₁₇O₂₅S
SMILES

O=C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CO)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C
Sequence

Ac-Ser-Leu-Lys-Leu-Met-Ala-Thr-Leu-Phe-Ser-Thr-Tyr-Ala-Ser-Ala-Asp
Sequence Shortening

Ac‐SLKLMATLFSTYASAD
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mirna M, et al. Autoimmune myocarditis is not associated with left ventricular systolic dysfunction. Eur J Clin Invest. 2019 Aug;49(8):e13132. doi: 10.1111/eci.13132 [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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