Myhc-α(334–352)
Based on 1 Customer Validation
Myhc-α(334–352) is a sequence fragment of amino acid residues 334 to 352 of cardiac myosin heavy chain α. Myhc-α(334–352) is an immunodominant epitope that can induce autoimmune reactions in A/J mice, leading to the occurrence of myocarditis. Myhc-α(334–352) can be used to study the autoimmune pathways of myocarditis and dilated cardiomyopathy.
For research use only. We do not sell to patients.
- Purity: 98.09%
- CAS No.: 171675-09-5
- Formula: C94H141N21O32
- Molecular Weight:2077.25
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Six-to-eight-week-old male and female C57BL/6 mice[2]
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Dosage:0, 1, 10, 100 μg/mL
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Administration:Subcutaneous injection (s.c.)
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Result:Breaked tolerance in Tg mice.
Resulted in development of myocarditis albeit with low severity.
Resulted in higher proliferative responses in CD4 T cells compared to CD8 T cells.
Primed Tg T cells that mainly produced IFN-γ.
Chemical Information
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CAS No. 171675-09-5
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Appearance Solid
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Molecular Weight 2077.25
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Formula C94H141N21O32
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Color White to off-white
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Sequence
Asp-Ser-Ala-Phe-Asp-Val-Leu-Ser-Phe-Thr-Ala-Glu-Glu-Lys-Ala-Gly-Val-Tyr-Lys
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Sequence Shortening
DSAFDVLSFTAEEKAGVYK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (24.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Massilamany C, et al. Identification of novel mimicry epitopes for cardiac myosin heavy chain-α that induce autoimmune myocarditis in A/J mice[J]. Cellular immunology, 2011, 271(2): 438-449. [Content Brief]
[2]. Sur, M., et al., (2023). Transgenic Mice Expressing Functional TCRs Specific to Cardiac Myhc-α 334-352 on Both CD4 and CD8 T Cells Are Resistant to the Development of Myocarditis on C57BL/6 Genetic Background. Cells, 12(19), 2346. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4814 mL | 2.4070 mL | 4.8141 mL | 12.0351 mL |
| 5 mM | 0.0963 mL | 0.4814 mL | 0.9628 mL | 2.4070 mL | |
| 10 mM | 0.0481 mL | 0.2407 mL | 0.4814 mL | 1.2035 mL | |
| 15 mM | 0.0321 mL | 0.1605 mL | 0.3209 mL | 0.8023 mL | |
| 20 mM | 0.0241 mL | 0.1204 mL | 0.2407 mL | 0.6018 mL |
Myhc-α(334–352) Related Classifications
HY-P10554 Related Classifications
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