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  5. Myosin H Chain Fragment, mouse acetate

Myosin H Chain Fragment, mouse acetate salt is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model.

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Myosin H Chain Fragment, mouse acetate Related Antibodies

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In Vivo Imaging
In Vivo Efficacy Study

    Myosin H Chain Fragment, mouse acetate purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2025 Jun 17.

    Ex vivo fluorescence images and quantitative data showing the accumulation of MTDR-labeled Mito in the hearts isolated from mice with or without experimental autoimmune myocarditis (EAM). To induce EAM, mice were subcutaneously immunized with 200 µg Myosin H Chain Fragment (HY-P2464) emulsified with CFA on days 0 and 7. In addition, pertussis toxin (500 ng) was injected intraperitoneally (i.p.) at the same time on day 0 to induce EAM in mice.

    Myosin H Chain Fragment, mouse acetate purchased from MedChemExpress. Usage Cited in: Mol Pharm. 2024 Jun 3;21(6):2865-2877.  [Abstract]

    To induce autoimmune myocarditis, 200 μg of myosin heavy chain fragment (HY-P2464), emulsified with complete Freund’s adjuvant (F5881; 1:1, w/w), was injected subcutaneously into 5-week-old male Balb/c mice on days 0 and 7.
    Left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were derived from M-mode echocardiography in the control group (Ctrl) and myocarditis group (Myo), respectively. Echocardiography revealed that both left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) showed significant reductions in the myocarditis group at day 21 compared with the control group.

    Myosin H Chain Fragment, mouse acetate purchased from MedChemExpress. Usage Cited in: Mol Pharm. 2024 Jun 3;21(6):2865-2877.  [Abstract]

    To induce autoimmune myocarditis, 200 μg Myosin H Chain Fragment (HY-P2464) emulsified with complete Freund adjuvant (F5881; 1:1, w/w) was injected subcutaneously in 5-week-old male Balb/c mice, on days 0 and 7.
    Serum cardiac troponin I (cTnI), creatine kinase (CK), creatine kinase-MB (CK-MB) in Ctrl group and Myo group, respectively. The results showed that the levels of cardiac troponin I (cTnI) and CK-MB were also significantly elevated in the myocarditis group at day 21 compared with the control group.

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    Description

    Myosin H Chain Fragment, mouse acetate salt is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model[1][2].

    In Vivo

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Myosin H Chain Fragment, mouse can be used in animal modeling to create myocarditis models[1][3].

    Induction of Myocarditis[1][2]
    Background
    Myosin H Chain Fragment, mouse causes myocarditis by inducing cardiac inflammation, triggering an autoimmune response and increasing leukocyte infiltration.
    Specific Modeling Methods
    Mice: Balb/c • male • 6-8 weeks old
    Administration: 150 μg • s.c. • days 0 and 7
    Note
    (1) Mice were divided into 2 groups, the control group contained 10 mice, and the Myosin H Chain Fragment, mouse induced group included 12 mice.
    (2) Echocardiography was performed on days 0, 7, and 21 using an anaesthesia system under continuous 2%-3% isoflurane anaesthesia, and the temperature of the mice was adjusted to 37 ± 0.5 °C using a heating pad and rectal probe.
    (3) Mice were executed 21 days after drug administration, and the hearts were immediately excised and cut along the short axis of the left ventricle at the level of the middle ventricle, then fixed overnight in 4% formaldehyde, paraffin sections were prepared and stained with hematoxylin and eosin for histopathological examination.
    Modeling Indicators
    Organizational changes: A marked inflammatory infiltrate was present, with a significant increase in left ventricular thickness.
    Echocardiography: Decreased left ventricular systolic function and increased left ventricular internal diastolic diameter (LVIDd) and systolic internal diameter (LVID).

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    2073.37 (free acid)

    Formula

    C91H149N25O28S.xC2H4O2
    Sequence

    Ac-Arg-Ser-Leu-Lys-Leu-Met-Ala-Thr-Leu-Phe-Ser-Thr-Tyr-Ala-Ser-Ala-Asp-Arg
    Sequence Shortening

    Ac-RSLKLMATLFSTYASADR
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    Myosin H Chain Fragment, mouse acetate Related Classifications

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Myosin H Chain Fragment, mouseOtherspeptideα-MyosinheavychainexperimentalautoimmunemyocarditisEAMInhibitorinhibitorinhibit

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