Myosin H Chain Fragment, mouse acetate

Cat. No.: HY-P2464A: Ficha de datos Instrucciones de manejo
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Myosin H Chain Fragment, mouse acetate salt is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model.

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Other In-stock Forms of Myosin H Chain Fragment, mouse acetate:

Myosin H Chain Fragment, mouse

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Myosin H Chain Fragment, mouse In-stock

3 Publications Citing Use of MCE Myosin H Chain Fragment, mouse acetate

In Vivo Imaging

In Vivo Efficacy Study

: Myosin H Chain Fragment, mouse acetate purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2025 Jun 17.; Ex vivo fluorescence images and quantitative data showing the accumulation of MTDR-labeled Mito in the hearts isolated from mice with or without experimental autoimmune myocarditis (EAM). To induce EAM, mice were subcutaneously immunized with 200 µg Myosin H Chain Fragment (HY-P2464) emulsified with CFA on days 0 and 7. In addition, pertussis toxin (500 ng) was injected intraperitoneally (i.p.) at the same time on day 0 to induce EAM in mice.

: Myosin H Chain Fragment, mouse acetate purchased from MedChemExpress. Usage Cited in: Mol Pharm. 2024 Jun 3;21(6):2865-2877. [Abstract]; To induce autoimmune myocarditis, 200 μg of myosin heavy chain fragment (HY-P2464), emulsified with complete Freund’s adjuvant (F5881; 1:1, w/w), was injected subcutaneously into 5-week-old male Balb/c mice on days 0 and 7.
Left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were derived from M-mode echocardiography in the control group (Ctrl) and myocarditis group (Myo), respectively. Echocardiography revealed that both left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) showed significant reductions in the myocarditis group at day 21 compared with the control group.

: Myosin H Chain Fragment, mouse acetate purchased from MedChemExpress. Usage Cited in: Mol Pharm. 2024 Jun 3;21(6):2865-2877. [Abstract]; To induce autoimmune myocarditis, 200 μg Myosin H Chain Fragment (HY-P2464) emulsified with complete Freund adjuvant (F5881; 1:1, w/w) was injected subcutaneously in 5-week-old male Balb/c mice, on days 0 and 7.
Serum cardiac troponin I (cTnI), creatine kinase (CK), creatine kinase-MB (CK-MB) in Ctrl group and Myo group, respectively. The results showed that the levels of cardiac troponin I (cTnI) and CK-MB were also significantly elevated in the myocarditis group at day 21 compared with the control group.

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Descripciòn	Myosin H Chain Fragment, mouse acetate salt is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model^[1]^[2].
In Vivo	Note: Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment. Myosin H Chain Fragment, mouse can be used in animal modeling to create myocarditis models^[1]^[3]. Induction of Myocarditis^[1]^[2] Background Myosin H Chain Fragment, mouse causes myocarditis by inducing cardiac inflammation, triggering an autoimmune response and increasing leukocyte infiltration. Specific Modeling Methods Mice: Balb/c • male • 6-8 weeks old Administration: 150 μg • s.c. • days 0 and 7 Note (1) Mice were divided into 2 groups, the control group contained 10 mice, and the Myosin H Chain Fragment, mouse induced group included 12 mice. (2) Echocardiography was performed on days 0, 7, and 21 using an anaesthesia system under continuous 2%-3% isoflurane anaesthesia, and the temperature of the mice was adjusted to 37 ± 0.5 °C using a heating pad and rectal probe. (3) Mice were executed 21 days after drug administration, and the hearts were immediately excised and cut along the short axis of the left ventricle at the level of the middle ventricle, then fixed overnight in 4% formaldehyde, paraffin sections were prepared and stained with hematoxylin and eosin for histopathological examination. Modeling Indicators Organizational changes: A marked inflammatory infiltrate was present, with a significant increase in left ventricular thickness. Echocardiography: Decreased left ventricular systolic function and increased left ventricular internal diastolic diameter (LVIDd) and systolic internal diameter (LVID). MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular	2073.37 (free acid)
Fòrmula	C₉₁H₁₄₉N₂₅O₂₈S._xC₂H₄O₂
Sequence	Ac-Arg-Ser-Leu-Lys-Leu-Met-Ala-Thr-Leu-Phe-Ser-Thr-Tyr-Ala-Ser-Ala-Asp-Arg
Sequence Shortening	Ac-RSLKLMATLFSTYASADR
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (277 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Moritz Mirna, et al. Autoimmune myocarditis is not associated with left ventricular systolic dysfunction. Eur J Clin Invest. 2019 Aug;49(8):e13132. [Content Brief] [2]. Ludwig T. Weckbach, et al. Blocking LFA-1 Aggravates Cardiac Inflammation in Experimental Autoimmune Myocarditis. Cells. 2019 Oct; 8(10): 1267. [Content Brief] [3]. Hoetzenecker K, et al. Mononuclear cell secretome protects from experimental autoimmune myocarditis[J]. European heart journal, 2015, 36(11): 676-685. [Content Brief]