N-Acetyl sulfadiazine-d₄ 

N-Acetyl sulfadiazine-d₄ is the deuterium labeled Triton X-45(n=4). Triton X-45 (n=4), a nonionic surfactant with a low hydrophile-lypophile balance (HLB) value and dispersible in aqueous solution at room temperature, has a Krafft point above the room temperature. Triton X-45 has the potential for the research of the hepatitis C virus (HCV)[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

296.34

C₁₂H₈D₄N₄O₃S

1219149-66-2

O=S(NC1=NC=CC=N1)(C2=C([2H])C([2H])=C(C([2H])=C2[2H])NC(C)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  [Content Brief]

  [2]. Wang Z, et al. Cloud point of nonionic surfactant Triton X-45 in aqueous solution. Colloids Surf B Biointerfaces. 2008;61(1):118-122.  [Content Brief]

  [3]. Chou ML, et al. TnBP⁄Triton X-45 treatment of plasma for transfusion efficiently inactivates hepatitis C virus. PLoS One. 2015;10(2):e0117800. Published 2015 Feb 6.  [Content Brief]