N,N'-(Ethane-1,2-diyl)bis(2-bromoacetamide)
Based on 1 Customer Validation
N,N'-(Ethane-1,2-diyl)bis(2-bromoacetamide) is a PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: ≥95.0%
- CAS No.: 4960-81-0
- Formula: C6H10Br2N2O2
- Molecular Weight:301.97
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
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Biological Activity
Description
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E745 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4960-81-0
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Appearance Solid
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Molecular Weight 301.97
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Formula C6H10Br2N2O2
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SMILES
O=C(NCCNC(=O)CBr)CBr
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (331.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (240 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3116 mL | 16.5579 mL | 33.1159 mL | 82.7897 mL |
| 5 mM | 0.6623 mL | 3.3116 mL | 6.6232 mL | 16.5579 mL | |
| 10 mM | 0.3312 mL | 1.6558 mL | 3.3116 mL | 8.2790 mL | |
| 15 mM | 0.2208 mL | 1.1039 mL | 2.2077 mL | 5.5193 mL | |
| 20 mM | 0.1656 mL | 0.8279 mL | 1.6558 mL | 4.1395 mL | |
| 25 mM | 0.1325 mL | 0.6623 mL | 1.3246 mL | 3.3116 mL | |
| 30 mM | 0.1104 mL | 0.5519 mL | 1.1039 mL | 2.7597 mL | |
| 40 mM | 0.0828 mL | 0.4139 mL | 0.8279 mL | 2.0697 mL | |
| 50 mM | 0.0662 mL | 0.3312 mL | 0.6623 mL | 1.6558 mL | |
| 60 mM | 0.0552 mL | 0.2760 mL | 0.5519 mL | 1.3798 mL | |
| 80 mM | 0.0414 mL | 0.2070 mL | 0.4139 mL | 1.0349 mL | |
| 100 mM | 0.0331 mL | 0.1656 mL | 0.3312 mL | 0.8279 mL |
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