1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. nAChR agonist CMPI hydrochloride

nAChR agonist CMPI hydrochloride 

Cat. No.: HY-136258
Handling Instructions

nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)3(β2)2 nAChR to ACh (10 µM) with an EC50 of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity.

For research use only. We do not sell to patients.

nAChR agonist CMPI hydrochloride Chemical Structure

nAChR agonist CMPI hydrochloride Chemical Structure

CAS No. : 2250025-94-4

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Description

nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4)3(β2)2 nAChR to ACh (10 µM) with an EC50 of 0.26 µM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity[1][2].

IC50 & Target

nAChR[1]

In Vitro

CMPI (0.01-10 µM) potentiates (α4)3(β2)2 (low ACh sensitivity) but not (α4)2(β2)3 (high ACh sensitivity) nAChRs in Xenopus laevis oocytes[1].
CMPI (0.01-10 µM) inhibits (α4)2(β2)3, human muscle and Torpedo nAChRs with IC50s of 0.6, 0.7 and 0.2 µM, respectively in Xenopus oocytes[1].

Molecular Weight

379.28

Formula

C₁₈H₂₀Cl₂N₄O

CAS No.

2250025-94-4

SMILES

CC1=C(C2=CC(C3=CC=CC=C3Cl)=NO2)C=NN1C4CCNCC4.[H]Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

nAChR agonist CMPInAChRNicotinic acetylcholine receptorsα4:α4(α4)3(β2)2nicotineneuropsychiatricInhibitorinhibitorinhibit

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nAChR agonist CMPI hydrochloride
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HY-136258
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