Nerve Growth Factor 7S,murine submaxillary gland 

Nerve Growth Factor 7S,murine submaxillary gland is a high-molecular-weight α₂β₂γ₂ neurotrophic factor complex isolated from murine submaxillary glands. Nerve Growth Factor 7S,murine submaxillary gland prevents the binding of active β-NGF dimers to neuronal receptors by sequestering the receptor-interacting region of β-NGF within the complex. Nerve Growth Factor 7S,murine submaxillary gland lacks neurotrophic activity due to the sequestration of β-NGF dimers and the occlusion of receptor-binding sites. Nerve Growth Factor 7S,murine submaxillary gland can be used in research related to neurodegenerative diseases^[1][2].

Nerve Growth Factor 7S,murine submaxillary gland reveals its α₂β₂γ₂ assembly, with extensive burying of the β-NGF dimer by α-NGF and γ-NGF subunits, explaining the complex's lack of neurotrophic activity, and zinc ions stabilizing α-NGF/γ-NGF interfaces^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

93928-24-6

[Nerve Growth Factor 7S,murine submaxillary gland]

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• [1]. Bax B, et al. Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure (London, England : 1993). 1997 Oct 15;5(10):1275-85.  [Content Brief]

  [2]. Guerina NG, et al. Comparison of 7S nerve growth factor and nerve growth factor I from mouse submandibular glands. Biochemistry. 1986 Feb 25;25(4):754-60.  [Content Brief]