Nerve Growth Factor 7S,murine submaxillary gland
Nerve Growth Factor 7S,murine submaxillary gland is a high-molecular-weight α2β2γ2 neurotrophic factor complex isolated from murine submaxillary glands. Nerve Growth Factor 7S,murine submaxillary gland prevents the binding of active β-NGF dimers to neuronal receptors by sequestering the receptor-interacting region of β-NGF within the complex. Nerve Growth Factor 7S,murine submaxillary gland lacks neurotrophic activity due to the sequestration of β-NGF dimers and the occlusion of receptor-binding sites. Nerve Growth Factor 7S,murine submaxillary gland can be used in research related to neurodegenerative diseases.
For research use only. We do not sell to patients.
- CAS No.: 93928-24-6
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Biological Activity
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Chemical Information
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Biological Activity
Description
In Vitro
Nerve Growth Factor 7S,murine submaxillary gland reveals its α2β2γ2 assembly, with extensive burying of the β-NGF dimer by α-NGF and γ-NGF subunits, explaining the complex's lack of neurotrophic activity, and zinc ions stabilizing α-NGF/γ-NGF interfaces[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 93928-24-6
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SMILES
[Nerve Growth Factor 7S,murine submaxillary gland]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Bax B, et al. Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure (London, England : 1993). 1997 Oct 15;5(10):1275-85. [Content Brief]
[2]. Guerina NG, et al. Comparison of 7S nerve growth factor and nerve growth factor I from mouse submandibular glands. Biochemistry. 1986 Feb 25;25(4):754-60. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nerve Growth Factor 7S,murine submaxillary gland Related Classifications
HY-NP144 Related Classifications
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