NR2F6 modulator-1

Name: NR2F6 modulator-1
Brand: MedChemExpress
SKU: HY-147228
Rating: 4.5 (0 reviews)

Cat. No.: HY-147228 Purity: 99.46%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

NR2F6 modulator-1 is a potent nuclear receptor subfamily 2, group F, member 6 (NR2F6) modulator. NR2F6 modulator-1 can be used for researching immune modulation and modulation of cancer stem cell activity.

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NR2F6 modulator-1 화학구조

CAS No. : 904449-84-9

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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•Related Screening Libraries:

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View All Checkpoint Kinase (Chk) Isoform Specific Products:

View All Isoforms

Chk1 Chk2 BUBR1

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

NR2F6^[1]

분자량

419.45

화학식

C₂₃H₁₇NO₅S

CAS No.

904449-84-9

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1OC2=C(C=C1S(=O)(C3=CC=CC=C3)=O)C=C(C(NCC4=CC=CC=C4)=O)C=C2

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 125 mg/mL (298.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3841 mL	11.9204 mL	23.8407 mL
5 mM	0.4768 mL	2.3841 mL	4.7681 mL
10 mM	0.2384 mL	1.1920 mL	2.3841 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.96 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.46%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (239 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Harry M., et al. Small molecule agonists and antagonists of nr2f6 activity. US20180346456A1 (compound C115)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3841 mL	11.9204 mL	23.8407 mL	59.6019 mL
	5 mM	0.4768 mL	2.3841 mL	4.7681 mL	11.9204 mL
	10 mM	0.2384 mL	1.1920 mL	2.3841 mL	5.9602 mL
	15 mM	0.1589 mL	0.7947 mL	1.5894 mL	3.9735 mL
	20 mM	0.1192 mL	0.5960 mL	1.1920 mL	2.9801 mL
	25 mM	0.0954 mL	0.4768 mL	0.9536 mL	2.3841 mL
	30 mM	0.0795 mL	0.3973 mL	0.7947 mL	1.9867 mL
	40 mM	0.0596 mL	0.2980 mL	0.5960 mL	1.4900 mL
	50 mM	0.0477 mL	0.2384 mL	0.4768 mL	1.1920 mL
	60 mM	0.0397 mL	0.1987 mL	0.3973 mL	0.9934 mL
	80 mM	0.0298 mL	0.1490 mL	0.2980 mL	0.7450 mL
	100 mM	0.0238 mL	0.1192 mL	0.2384 mL	0.5960 mL