NSC309401 dihydrochloride
NSC309401 is an inhibitor of E. coli DHFR (IC50: 189 nM, KD: 14.57 nM).
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- CAS. Nr.: 77681-42-6
- Formel: C17H18Cl2N6
- Molecular Weight:377.27
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
189 nM (E. coli DHFR)[1]
Chemical Information
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CAS. Nr. 77681-42-6
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Molecular Weight 377.27
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Formel C17H18Cl2N6
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SMILES
NC(C=C1)=CC=C1CN2C=CC3=C4C(N=C(N)N=C4N)=CC=C32.Cl.Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Srinivasan B, et al. Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors. FEBS J. 2015 May;282(10):1922-38. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NSC309401 dihydrochloride Related Classifications
HY-156859 Related Classifications
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