Cationic Lipids
The molecular architecture of cationic lipids used as nucleic acid carriers is similar to that of natural lipids, with the major difference being their cationic head group, so cationic lipids have the ability to form aggregate complexes with anionic nucleic acids such as DNA or RNA. Advantages of cationic lipid-mediated transfection include high efficiency, ability to transfect a wide range of cell types, reproducibility, and simplicity.
Ionizable cationic lipids (including DOTMA, DODAP, DLin-KC2-DMA, and D-Lin-MC3-DMA) are pH sensitive and highly effective for in vivo transfection. These ionizable cationic lipids are positively charged at low pH (the ability to complex nucleic acids), but mostly uncharged at the pH of blood (pH 7.4) (slow elimination and good tolerability). The ionizable cationic lipids shape and acid-dissociation constant optimization dramatically improved lipid nanoparticles (LNPs) potency, thereby enabling clinical translation.
- Formula: C94H194N4O6
- Molecular Weight: 1476.57
C14-SPM is a polyamine branched-chain lipidoid that can be used for the delivery of siRNA.
- Formula: C43H85NO4
- Molecular Weight: 680.14
Lipid 11 (Compound Lipid 1) is a cationic lipid for nucleic acid delivery. Lipid 11 forms lipid nanoparticles (LNPs) through electrostatic binding with nucleic acids (such as ceDNA). Lipid 11 forms complexes with negatively charged nucleic acids via cationic amine groups, which can be endocytosed by cells to release nucleic acids for activity. Lipid 11 is promising for research of gene therapy drug delivery systems.
- Formula: C37H73ClN2O5
- Molecular Weight: 661.44
DC-6-14 is a cationic lipid with gene transfection activity, which can be used for the synthesis of liposomes.
- Formula: C42H84ClNO4
- Molecular Weight: 702.57
DSTAP chloride (CDESA) is a cationic lipid that used in the formation of lipid nanoparticles (LNPs). DORI chloride has high transfection efficiency.
- Formula: C44H82N4O
- Molecular Weight: 683.15
LNP Lipid-5 (Compound Lipid 2) is an ionizable lipid (amino lipid). LNP Lipid-5 can be used to prepare lipid nanoparticles (LNP).
- Formula: C45H80N2NaO9PS2
- Molecular Weight: 911.22
16:0 PDP PE belongs to a class of head group modified functionalized lipids. 16:0 PDP PE has been used in preparation of rhodamine high-density lipoprotein nanoparticle (Rh-HDL NP) synthesis.
- Formula: C48H97N3O4
- Molecular Weight: 780.30
LNP Lipid-6 (Compound Lipid 5) is an ionizable lipid (amino lipid). LNP Lipid-6 can be used to prepare lipid nanoparticles (LNP).
- Formula: C43H85NO5
- Molecular Weight: 696.14
- Formula: C19H35N3O8
- Molecular Weight: 433.50
Bis(bis(2-carboxyethyl)aminopropyl)methylamine is a symmetrical branched linker featuring three tertiary amines and four carboxylic acids. Each carboxylic acid is open to forming esters or amides. It can be used in developing lipid nanoparticles.
- Formula: C73H144N4O8
- Molecular Weight: 1205.95
503O13 is a degradable ionizable lipid for siRNA delivery.
- Formula: C43H77ClN2O4
- Molecular Weight: 721.54
DOIC is a cationic lipid that can be used for RNA vaccines.
- Formula: C44H87NO5
- Molecular Weight: 710.17
Lipid M (pKa: 6.75) can be used to deliver mRNA vaccine and yield a robust immune response with improved tolerability.
- Formula: C36H66N8O2
- Molecular Weight: 642.96
BGTC is a non-amino acid cationic lipid. BGTC can be used for delivery of nucleic acids.
- Formula: C46H93ClNO8P
- Molecular Weight: 854.66
18:0 EPC chloride is a synthetic cationic phospholipid. 18:0 EPC chloride (at the critical synergistic concentrations of 2.34-2.93 μM) significantly improves the inactivation effect of eugenol against Escherichia coli.
- Formula: C36H75N
- Molecular Weight: 521.99
Dioctadecylamine (DODA) is a secondary amine that has been shown to self-organize in plate-like structures in aqueous solution. Dioctadecylamine exhibits sufficiently hydrophobic properties of nanoparticles and good dispersibility in nonpolar solvent. Dioctadecylamine does not form a monolayer above pH 3.9.
- Formula: C49H95NO6
- Molecular Weight: 794.28
L-369 is an ionizable cationic lipid that can be used to synthesize lipid nanoparticles and deliver mRNA.
- Formula: C12H24ClNO4
- Molecular Weight: 281.78
Valeryl-L-carnitine (chloride) is an ester product.
- Formula: C10H17NO6
- Molecular Weight: 247.25
cis-Malonylcarnitine is an ester product.
- Formula: C42H80ClNO4
- Molecular Weight: 698.54
1,2-Dioleoyl-3(S)-trimethylammoniumpropane chloride is a biochemical reagent.
