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Cat. No.: HY-132289

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Lipid M

Lipid M (pKa: 6.75) can be used to deliver mRNA vaccine and yield a robust immune response with improved tolerability.

For research use only. We do not sell to patients.

CAS No.: 2089251-57-8
Formula: C₄₄H₈₇NO₅
Molecular Weight:710.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

Lipid M Chemical Structure

CAS No.: 2089251-57-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Lipid M (pKa: 6.75) can be used to deliver mRNA vaccine and yield a robust immune response with improved tolerability^[1].

In Vivo

Lipid M (50 μL containing 2 μg of luciferase mRNA formulated in LNPs, i.m.) is followed by rapid clearance in muscle, spleen and liver in CD-1 mice^[1].
Lipid M (300 μL containing 500 μg IgG mRNA formulated in LNPs, i.m.) yields serum antibody expression comparable to that of MC3-based LNPs in cynomolgus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2089251-57-8
Molecular Weight 710.17
Formula C₄₄H₈₇NO₅
SMILES

OCCN(CCCCCCCOC(C(CCCCCCCC)CCCCCCCC)=O)CCCCCCCC(OCCCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hassett KJ, et al. Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines. Mol Ther Nucleic Acids. 2019 Apr 15;15:1-11. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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- In Vivo
Chemical Information
Purity & Documentation
References

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Lipid M

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Biological Activity

Chemical Information

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Lipid M Related Classifications

HY-132289 Related Classifications