PD-1/PD-L1 antagonist 1
PD-1/PD-L1 antagonist 1 (Compound A5) is an antagonist for programmed cell death-1 (PD-1) and programmed cell death ligand-1 (PD-L1) interaction, with an IC50 of 23.78 nM.
For research use only. We do not sell to patients.
- Formula: C52H48Cl2N6O8
- Molecular Weight:955.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
23.78 nM (PD-1/PD-L1 interaction)
PD-1/PD-L1 antagonist 1 (0-3 μM) dose-dependently inhibits PD-1 and PD-L1 interaction in a co-system of Jurkat-NFAT-PD-1 cells and Hep3B-OS8-hPD-L1 cells, exhibits no significant cytotoxicity in Jurkat cells with a safe dose of 3.3 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat
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Concentration:0-30 μM
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Incubation Time:48 h
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Result:Maintained the cell viability with concentration less than 3.3 μM. Reduced cell viability at 10 and 30 μM.
Chemical Information
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Molecular Weight 955.88
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Formula C52H48Cl2N6O8
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SMILES
ClC(C=C1CNC[C@H](CO)O)=C(C=C1OCC2=CC(C#N)=CC=C2)OCC3=CC=CC(C4=CC=CC5=C4N=CN=C5OC6=CC(OCC7=CC=CC(C#N)=C7)=C(C=C6Cl)CNC[C@H](CO)O)=C3C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-1/PD-L1 antagonist 1 Related Classifications
HY-158052 Related Classifications
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