PD-1/PD-L1-IN-61
PD-1/PD-L1-IN-61 is a PD-1/PD-L1 interaction inhibitor with a human IC50 of 5.3 nM. PD-1/PD-L1-IN-61 embeds into the hydrophobic pocket at the PD-L1 dimer interface, stabilizing binding through hydrogen bonds and π-π stacking with PD-L1 residues. PD-1/PD-L1-IN-61 acts as an immune activator, enhances immune-killing activity of peripheral blood mononuclear cells against cancer cells, restores T-cell immune function, and promotes IFN-γ secretion. PD-1/PD-L1-IN-61 can be used for the research of triple-negative breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2983098-90-2
- Formula: C42H44N6O9
- Molecular Weight:776.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
PD-1/PD-L1-IN-61 (III-4) (1-16 μM) shows negligible cytotoxicity against MDA-MB-231 and Jurkat cells[1].
PD-1/PD-L1-IN-61 (0.5-2 μM) dose-dependently enhances PBMC-mediated killing of MDA-MB-231 cells, inducing 38.4% tumor cell killing at 1 μM[1].
PD-1/PD-L1-IN-61 (10-1000 nM) dose-dependently promotes IFN-γ secretion from hPBMCs, with significant increases at 100 nM and 1000 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 and Jurkat cells
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Concentration:1, 2, 4 ,8, 16 μM
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Incubation Time:null
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Result:Showed negligible cytotoxicity against MDA-MB-231 and Jurkat cells in a CCK-8 assay.
Chemical Information
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CAS No. 2983098-90-2
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Molecular Weight 776.83
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Formula C42H44N6O9
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SMILES
OC(CC1)CCN1CC(O2)=NN=C2C3=C(C)C(C4=CC=CC(COC5=C([N+]([O-])=O)C=C(CN[C@@H](C(C)O)C(O)=O)C(OCC6=CC(C#N)=CC=C6)=C5)=C4C)=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-1/PD-L1-IN-61 Related Classifications
HY-182047 Related Classifications
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