PD-1/PD-L1-IN-66
PD-1/PD-L1-IN-66 is a PD-1/PD-L1 immune checkpoint inhibitor with an IC50 of 3 nM for blocking the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-66 shows good affinity for PD-L1 dimers with a Kd value of 0.75 nM. PD-1/PD-L1-IN-66 can reactivate the proliferation of cytotoxic T cells. PD-L1 ligand-2 is applicable for cancer research.
For research use only. We do not sell to patients.
- Formula: C15H9Cl3N2O
- Molecular Weight:339.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
PD-1/PD-L1-IN-66 (Compound 12) binds to purified PD-L1 protein with a Kd of 7 nM and to the PD-L1 dimer with a Kd of 0.75 nM[1].
PD-1/PD-L1-IN-66 reactivates proliferation of hPD-L1-exposed CTLL-2 cytotoxic T-cells with an IC50 of 124 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 339.60
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Formula C15H9Cl3N2O
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SMILES
O=C1CC(C2=CC=C(C=C2)Cl)=NN1C3=C(C=C(C=C3)Cl)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)