PD-1/PD-L1-IN-68
PD-1/PD-L1-IN-68 is a PD-L1 inhibitor based on a tetrahydroisoquinoline scaffold, with a KD of 21.31 μM for binding to hPD-L1, and it blocks the PD-1/PD-L1 interaction. PD-1/PD-L1-IN-68 restores T cell immune function, thereby promoting the death of PD-L1+ cancer cells. PD-1/PD-L1-IN-68 can be used in studies related to liver cancer.
For research use only. We do not sell to patients.
- CAS No.: 3056281-16-1
- Formula: C29H32N2O3
- Molecular Weight:456.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hPD-L1 21.31 μM (Kd) |
PD-1/PD-L1-IN-68 (compound Y7f) at 50 μM inhibits the interaction between PD-1 and PD-L1 proteins in in vitro HTRF assays[1].
PD-1/PD-L1-IN-68 binds to hPD-L1 protein in in vitro SPR assays, with a KD value of 21.31 μM[1].
PD-1/PD-L1-IN-68 (1.11 μM; 48 h) exerts a 42% inhibitory effect on HepG2 cell viability in a co-culture system of IFN-γ-prestimulated PD-L1+ HepG2 cells and PHA-activated PD-1+ Jurkat cells, and shows superior activity to 10 μM BMS-1[1].
PD-1/PD-L1-IN-68 (1.1 μM; 24 h) significantly reverses the inhibitory effect of hPD-L1 on IFN-γ secretion by Jurkat cells activated with anti-CD3/CD28, whereas Y7f alone does not directly stimulate IFN-γ release from Jurkat cells[1].
The maximum non-significant cytotoxic concentrations of PD-1/PD-L1-IN-68 (48 h) against HepG2 and Jurkat cells are 3.33 μM and 1.11 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2, Jurkat
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Concentration:3.33 μM (HepG2); 1.11 μM (Jurkat)
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Incubation Time:48 h
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Result:Demonstrated a maximum non-toxic concentration of 3.33 μM in HepG2 cells and 1.11 μM in Jurkat cells.
Chemical Information
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CAS No. 3056281-16-1
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Molecular Weight 456.58
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Formula C29H32N2O3
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SMILES
COC1=C(CC(N2CCC(O)C2)=O)C=C(CCNC3CC4=CC=C(C5=CC=CC=C5)C=C4)C3=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PD-1/PD-L1-IN-68 Related Classifications
HY-187712 Related Classifications
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