1. Apoptosis
    Immunology/Inflammation
    Protein Tyrosine Kinase/RTK
    NF-κB
  2. Apoptosis
    COX
    VEGFR
    NF-κB
  3. Pentagamavunon-1

Pentagamavunon-1 (Synonyms: PGV-1)

Cat. No.: HY-136477 Purity: 99.80%
Handling Instructions

Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation.

For research use only. We do not sell to patients.

Pentagamavunon-1 Chemical Structure

Pentagamavunon-1 Chemical Structure

CAS No. : 27060-70-4

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10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
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100 mg USD 550 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Pentagamavunon-1 (PGV-1), a Curcumin analog with oral activity, targets on several molecular mechanisms to induce apoptosis including inhibition of angiogenic factors cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF). PGV-1 inhibits NF-κB activation[1].

In Vitro

Pentagamavunon-1 (PGV-1, 1, 2.5, 5, 7.5, 10, 15, and 20 µM) enhances cytotoxic effect of 5-FU on WiDr cells[1].
Pentagamavunon-1 (PGV-1, 1, 2.5, 5, and 10 µM) shows different effects on cell cycle progression and induces G2/M arrest[1].

Cell Viability Assay[1].

Cell Line: Human colon carcinoma WiDr.
Concentration: 1, 2.5, 5, 7.5, 10, 15, and 20 µM.
Incubation Time: 6, 12, 24, and 48 hours.
Result: Significantly enhanced the cytotoxicity of 5-FU on WiDr cells at various concentrations during 6, 12, 24, and 48 h incubation.

Cell Cycle Analysis[1].

Cell Line: WiDr cells.
Concentration: 1, 2.5, 5, and 10 µM.
Incubation Time: 24 h.
Result: The non-treated WiDr cells showed cell accumulation in G1, S, and G2/M phase about 50.85%, 36.11% and 13.04%, respectively.
In Vivo

Pentagamavunon-1 (PGV-1, po, 20 mg/kg) exhibits significant anti-tumor activity in PDX model, without obvious toxicity[1].

Animal Model: Human cancer cells in a xenograf mouse model[2].
Dosage: 20mg/kg.
Administration: P.O. every 2 days for 20 days.
Result: Exhibited little decrease in body weight, nor a decrease in white and red blood cell counts in peripheral blood, nor any other efects in behavior and macroscopic appearance. Thus, PGV-1 was sufciently potent to suppress tumor formation in vivo, but exhibited little or no obvious adverse effects on the normal lineage of cells.
Molecular Weight

348.43

Formula

C₂₃H₂₄O₃

CAS No.

27060-70-4

SMILES

O=C1/C(CC/C1=C\C2=CC(C)=C(O)C(C)=C2)=C/C3=CC(C)=C(O)C(C)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (143.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8700 mL 14.3501 mL 28.7002 mL
5 mM 0.5740 mL 2.8700 mL 5.7400 mL
10 mM 0.2870 mL 1.4350 mL 2.8700 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (5.97 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 2.08 mg/mL (5.97 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

Pentagamavunon-1PGV-1Pentagamavunon1Pentagamavunon 1PGV1PGV 1ApoptosisCOXVEGFRNF-κBCyclooxygenaseVascular endothelial growth factor receptorNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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