IFN-alpha 4

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IFN-alpha 4 (IFNA4; IFN-α4), belongs to the alpha/beta interferon (IFN) family, is produced by the macrophages with antiviral activities. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively^[1].
Interferon alpha (IFNa) shows significant biological activity in various cancers, paticularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia^[2].
IFN-alpha 4 is the subtypes dominates in IFN-alpha, whose the response with IFNA5, IFNA7, and IFNA14 accounting for up to 85% of the subtypes expressed by Peripheral blood mononuclear cells (PBMCs)^[3].
IFN-alpha 4 is promoted by interferon (IFN) regulatory factors (IRFs), especially IRF-1 and IRF-7^[5]^[6]. And it exhibits function by inhibiting virus RNA replication and enhances human natural killer cytotoxicity against virus^[4]^[7].

References:

[1]. Zhang SY, et al. Inborn errors of interferon (IFN)-mediated immunity in humans: insights into the respective roles of IFN-alpha/beta, IFN-gamma, and IFN-lambda in host defense. Immunol Rev. 2008 Dec;226:29-40. [Content Brief]

[2]. Raj NB, et al. Identification of a novel virus-responsive sequence in the promoter of murine interferon-alpha genes. J Biol Chem. 1991 Jun 15;266(17):11360-5. [Content Brief]

[3]. Li Y, et al. Expression Pattern of Individual IFNA Subtypes in Chronic HIV Infection. J Interferon Cytokine Res. 2017 Dec;37(12):541-549. [Content Brief]

[4]. Verhagen A, et al. Comparison of augmentation of human natural killer cell cytotoxicity by interferon-alpha subtypes. Nat Immun Cell Growth Regul. 1990;9(5):325-33. [Content Brief]

[5]. Au WC, et al. Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes. Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11657-61. [Content Brief]

[6]. Lin R, et al. Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7. Mol Cell Biol. 2000 Sep;20(17):6342-53. [Content Brief]

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IFN-alpha 4 Recombinant Proteins (6)

Species:	Human (3) Mouse (1) Rat (1) Cynomolgus (1)
Tag:	His (3) Fc (3)
Source:	HEK293 (5) Sf9 insect cells (1)

Cat. No.	Product Name / Synonyms	Species	Source

HY-P76403

IFN-alpha 4/IFNA4 Protein, Mouse (HEK293, His) Interferon alpha-4; IFN-alpha-4; INFA4	Mouse	HEK293
IFN-alpha 4 (IFNA4), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 4/IFNA4 Protein, Mouse (HEK293, His) contains 162 a.a. (C25-E186), produced in HEK293 cells with a C-terminal His-tag.

HY-P76983

IFN-alpha 4/IFNA4 Protein, Rat (HEK293, Fc) Interferon alpha-4; Interferon alpha-4B; Interferon alpha-76	Rat	HEK293
IFN-alpha 4 (IFNA4), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 4/IFNA4 Protein, Rat (HEK293, Fc) contains 166 a.a. (C24-K189), produced in HEK293 cells with a N-terminal hFc-tag.

HY-P77391

IFN-alpha 4 Protein, Cynomolgus (HEK293, Fc) Interferon alpha-4; IFN-alpha-4; INFA4	Cynomolgus	HEK293
IFN-alpha 4 (IFNA4), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 4 Protein, Cynomolgus (HEK293, Fc) contains 189 a.a. (M1-N189), produced in HEK293 cells with a C-terminal mFc-tag.

HY-P72615

IFN-alpha 4/IFNA4 Protein, Human (HEK293, His) Interferon alpha-4; Interferon alpha-4B; Interferon alpha-76; Interferon alpha-M1; IFNA4	Human	HEK293
IFN-alpha 4 (IFNA4), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 4/IFNA4 Protein, Human (HEK293, His) contains 166 a.a. (C24-D189), produced in HEK293 cells cells with a C-terminal His-tag.

HY-P75821

IFN-alpha 4/IFNA4 Protein, Human (HEK293, Fc) Interferon alpha-4; Interferon alpha-76; IFNA4	Human	HEK293
IFN-alpha 4 (IFNA4), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 4/IFNA4 Protein, Human (HEK293, Fc) contains 166 a.a. (C24-D189), produced in HEK293 cells with a N-terminal hFc-tag.

HY-P75822

IFN-alpha 4/IFNA4 Protein, Human (sf9, His) Interferon alpha-4; Interferon alpha-76; IFNA4	Human	Sf9 insect cells
IFN-alpha 4 (IFNA4), belongs to type I interferon family, is produced by macrophages with antiviral activities. IFN-alpha 4/IFNA4 Protein, Human (sf9, His) contains 189 a.a. (M1-D189), produced in Sf9 insect cells cells with a C-terminal His-tag.

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IFN-alpha 4

IFN-alpha 4

Subscribe Now to the List of Recombinant Proteins

IFN-alpha 4 Recombinant Proteins (6)