Nicotinamide N-oxides as CXCR2 antagonists

  • Bioorg Med Chem Lett. 2001 Jul 23;11(14):1951-4. doi: 10.1016/s0960-894x(01)00326-2.
N S Cutshall  1 ,  R Ursino ,  K A Kucera ,  J Latham ,  N C Ihle
Affiliations
  • 1. Department of Chemistry, Celltech R&D, Inc., 1631 220th Street SE, 98021, Bothell, WA, USA. [email protected]
PMID: 11459668 DOI: 10.1016/s0960-894x(01)00326-2
Abstract

A series of nicotinamide N-oxides was synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Furthermore, these compounds showed significant functional activity against GRO-alpha-driven human neutrophil chemotaxis. Compounds of this class may be useful for the treatment of inflammatory, auto-immune, and allergic disorders.

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