Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase

  • Arch Pharm Res. 2007 Apr;30(4):397-401. doi: 10.1007/BF02980210.
Xiang Hua Han  1 ,  Seong Su Hong ,  Dongho Lee ,  Jung Joon Lee ,  Moon Soon Lee ,  Dong-Cheul Moon ,  Kun Han ,  Ki-Wan Oh ,  Myung Koo Lee ,  Jai Seup Ro ,  Bang Yeon Hwang
Affiliations
  • 1. College of Pharmacy, Chungbuk National University, Cheongju, Korea.
PMID: 17489352 DOI: 10.1007/BF02980210
Abstract

1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B Inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone Alkaloids, 1-methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-undecenyl]-4(1H)-quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots.

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