Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma

  • Inflamm Res. 2007 Oct;56(10):402-8. doi: 10.1007/s00011-007-7005-6.
A P Rogerio  1 ,  A Kanashiro ,  C Fontanari ,  E V G da Silva ,  Y M Lucisano-Valim ,  E G Soares ,  L H Faccioli
Affiliations
  • 1. Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Ribeirão Preto, Brasil.
PMID: 18026696 DOI: 10.1007/s00011-007-7005-6
Abstract

Objective: Eosinophils and cytokines are implicated in the pathogenesis of allergic diseases. In the present study, we investigate the anti-inflammatory effect of quercetin and isoquercitrin in a murine model of Asthma.

Methods: BALB/c mice were immunized (ovalbumin/aluminum hydroxide, s. c.), followed by two intranasal ovalbumin challenges. From day 18 to day 22 after the first immunization, the mice received daily gavages of isoquercitrin (15 mg/kg) or quercetin (10 mg/kg). Dexamethasone (1 mg/kg, s. c.) was administered as a positive control. Leucocytes were analyzed in bronchoalveolar lavage fluid (BALF), blood and pulmonary parenchyma at 24 h after the last ovalbumin challenge. Interleukin-5 (IL-5) was analyzed in BALF and lung homogenates.

Results: In Animals receiving isoquercitrin or quercetin, eosinophil counts were lower in the BALF, blood and lung parenchyma. Neutrophil counts in blood and IL-5 levels in lung homogenate were lower only in isoquercitrin-treated mice. No alterations in mononuclear cell numbers were observed.

Conclusion: Quercetin and isoquercitrin are effective eosinophilic inflammation suppressors, suggesting a potential for treating allergies.

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