Hepatoprotective Dibenzocyclooctadiene and Tetrahydrobenzocyclooctabenzofuranone Lignans from Kadsura longipedunculata

  • J Nat Prod. 2018 Apr 27;81(4):846-857. doi: 10.1021/acs.jnatprod.7b00934.
Jiabao Liu  1 ,  Pankaj Pandey ,  Xiaojuan Wang  2 ,  Xinzhu Qi  1 ,  Jiabao Chen  1 ,  Hua Sun  1 ,  Peicheng Zhang  1 ,  Yuanqing Ding ,  Daneel Ferreira ,  Robert J Doerksen ,  Mark T Hamann  2 ,  Shuai Li  1
Affiliations
  • 1. State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , People's Republic of China.
  • 2. Department of Drug Discovery and Biomedical Sciences, College of Pharmacy , Medical University of South Carolina , Charleston , South Carolina 29425 , United States.
PMID: 29595972 DOI: 10.1021/acs.jnatprod.7b00934
Abstract

Five new dibenzocyclooctadiene Lignans, longipedlignans A-E (1-5), five new tetrahydrobenzocyclooctabenzofuranones (6-10), and 18 known analogues (11-28) were isolated from the roots of Kadsura longipedunculata. Compounds 6-10 are new spirobenzofuranoid-dibenzocyclooctadiene-type Lignans. Their structures and absolute configurations were established using a combination of MS, NMR, and electronic circular dichroism data. Spirobenzofuranoids 6 and 15 showed moderate hepatoprotective activity against N-acetyl- p-aminophenol-induced toxicity in HepG2 cells with cell survival rates at 10 μM of 52.2% and 50.2%, respectively.

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