Racheting Up Repair

  • Immunity. 2018 Oct 16;49(4):577-579. doi: 10.1016/j.immuni.2018.09.012.
Jovylyn Gatchalian  1 ,  Diana C Hargreaves  2
Affiliations
  • 1. Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla CA, USA.
  • 2. Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, La Jolla CA, USA. Electronic address: [email protected].
PMID: 30332621 DOI: 10.1016/j.immuni.2018.09.012
Abstract

In this issue of Immunity, Daniel et al. (2018a) demonstrate that the nuclear receptor PPARγ acts in a ligand-insensitive manner to impart transcriptional memory and enhanced functionality to IL-4 polarized Macrophages. Their findings shed light on the mechanisms that control priming of the epigenome in response to inflammatory signals.